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\"title\": \"IDRA-21, a positive AMPA receptor modulator, inhibits synaptic and extrasynaptic NMDA receptor mediated events in cultured cerebellar granule cells.\",\n        \"author\": [\n            {\n                \"family\": \"G\",\n                \"given\": \"Losi\"\n            },\n            {\n                \"family\": \"G\",\n                \"given\": \"Puia\"\n            },\n            {\n                \"family\": \"al.\",\n                \"given\": \"Braghiroli D et\"\n            }\n        ],\n        \"container-title\": \"Neuropharmacology\",\n        \"issued\": {\n            \"date-parts\": [\n                [\n                    2004\n                ]\n            ]\n        },\n        \"DOI\": \"10.1016\\\/j.neuropharm.2004.02.011\",\n        \"PMID\": 15111017,\n        \"URL\": \"http:\\\/\\\/hdl.handle.net\\\/11380\\\/1248326\"\n    },\n    {\n        \"id\": \"molgod-c182274621c0a505ec602a7be9ff629d\",\n        \"type\": \"article-journal\",\n        \"title\": \"Modulating excitatory synaptic neurotransmission: potential treatment for neurological disease?\",\n        \"author\": [\n            {\n                \"family\": \"KA\",\n                \"given\": \"Yamada\"\n            }\n        ],\n        \"container-title\": \"Neurobiology of disease\",\n        \"issued\": {\n            \"date-parts\": [\n                [\n                    1998\n                ]\n            ]\n        },\n        \"DOI\": \"10.1006\\\/nbdi.1998.0190\",\n        \"PMID\": 9746904,\n        \"URL\": \"https:\\\/\\\/doaj.org\\\/article\\\/40ec9f3bf6f14fb495a26fc80a5c3f79\"\n    },\n    {\n        \"id\": \"molgod-3188ab8ea46b22d29e6de894c6cd6c3b\",\n        \"type\": \"article-journal\",\n        \"title\": \"Probing the allosteric modulator binding site of GluR2 with thiazide derivatives.\",\n        \"author\": [\n            {\n                \"family\": \"CP\",\n                \"given\": \"Ptak\"\n            },\n            {\n                \"family\": \"AH\",\n                \"given\": \"Ahmed\"\n            },\n            {\n                \"family\": \"RE\",\n                \"given\": \"Oswald\"\n            }\n        ],\n        \"container-title\": \"Biochemistry\",\n        \"issued\": {\n            \"date-parts\": [\n                [\n                    2009\n                ]\n            ]\n        },\n        \"DOI\": \"10.1021\\\/bi901127s\",\n        \"PMID\": 19673491,\n        \"URL\": \"https:\\\/\\\/www.ncbi.nlm.nih.gov\\\/pmc\\\/articles\\\/2756660\"\n    },\n    {\n        \"id\": \"molgod-e9a6dadea26d1fcd72f4b26b7e1afacd\",\n        \"type\": \"article-journal\",\n        \"title\": \"Modulation of kainate--activated currents by diazoxide and cyclothiazide analogues (IDRA) in cerebellar granule neurons.\",\n        \"author\": [\n            {\n                \"family\": \"G\",\n                \"given\": \"Puia\"\n            },\n            {\n                \"family\": \"G\",\n                \"given\": \"Losi\"\n            },\n            {\n                \"family\": \"al.\",\n                \"given\": \"Razzini G et\"\n            }\n        ],\n        \"container-title\": \"Progress in neuro-psychopharmacology & biological psychiatry\",\n        \"issued\": {\n            \"date-parts\": [\n                [\n                    2000\n                ]\n            ]\n        },\n        \"DOI\": \"10.1016\\\/s0278-5846(00)00120-2\",\n        \"PMID\": 11041540,\n        \"URL\": \"http:\\\/\\\/hdl.handle.net\\\/11380\\\/305791\"\n    },\n    {\n        \"id\": \"molgod-21e30acc26e2c34661e347fa9ba96c14\",\n        \"type\": \"article-journal\",\n        \"title\": \"The effects of IDRA 21, a positive modulator of the AMPA receptor, on delayed matching performance by young and aged rhesus monkeys.\",\n        \"author\": [\n            {\n                \"family\": \"JJ\",\n                \"given\": \"Buccafusco\"\n            },\n            {\n                \"family\": \"T\",\n                \"given\": \"Weiser\"\n            },\n            {\n                \"family\": \"al.\",\n                \"given\": \"Winter K et\"\n            }\n        ],\n        \"container-title\": \"Neuropharmacology\",\n        \"issued\": {\n            \"date-parts\": [\n                [\n                    2004\n                ]\n            ]\n        },\n        \"DOI\": \"10.1016\\\/j.neuropharm.2003.07.002\",\n        \"PMID\": 14654093\n    },\n    {\n        \"id\": \"molgod-4ee9049e9d3b54e433dc4ba331bcd72c\",\n        \"type\": \"article-journal\",\n        \"title\": \"7-Chloro-3-methyl-3-4-dihydro-2H-1,2,4 benzothiadiazine S,S-dioxide (IDRA 21): a benzothiadiazine derivative that enhances cognition by attenuating DL-alpha-amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid (AMPA) receptor desensitization.\",\n        \"author\": [\n            {\n                \"family\": \"I\",\n                \"given\": \"Zivkovic\"\n            },\n            {\n                \"family\": \"DM\",\n                \"given\": \"Thompson\"\n            },\n            {\n                \"family\": \"al.\",\n                \"given\": \"Bertolino M et\"\n            }\n        ],\n        \"container-title\": \"The Journal of pharmacology and experimental therapeutics\",\n        \"issued\": {\n            \"date-parts\": [\n                [\n                    1995\n                ]\n            ]\n        },\n        \"PMID\": 7815345\n    },\n    {\n        \"id\": \"molgod-f9fdede70b0b055d25f4aef74feab1c3\",\n        \"type\": \"article-journal\",\n        \"title\": \"7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide (IDRA 21), a congener of aniracetam, potently abates pharmacologically induced cognitive impairments in patas monkeys.\",\n        \"author\": [\n            {\n                \"family\": \"DM\",\n                \"given\": \"Thompson\"\n            },\n            {\n                \"family\": \"A\",\n                \"given\": \"Guidotti\"\n            },\n            {\n                \"family\": \"al.\",\n                \"given\": \"DiBella M et\"\n            }\n        ],\n        \"container-title\": \"Proceedings of the National Academy of Sciences of the United States of America\",\n        \"issued\": {\n            \"date-parts\": [\n                [\n                    1995\n                ]\n            ]\n        },\n        \"DOI\": \"10.1073\\\/pnas.92.17.7667\",\n        \"PMID\": 7644474\n    },\n    {\n        \"id\": \"molgod-b869fa63f77c944afe771ed07b386d72\",\n        \"type\": \"article-journal\",\n        \"title\": \"The diazoxide derivative IDRA 21 enhances ischemic hippocampal neuron injury.\",\n        \"author\": [\n            {\n                \"family\": \"KA\",\n                \"given\": \"Yamada\"\n            },\n            {\n                \"family\": \"DF\",\n                \"given\": \"Covey\"\n            },\n            {\n                \"family\": \"al.\",\n                \"given\": \"Hsu CY et\"\n            }\n        ],\n        \"container-title\": \"Annals of neurology\",\n        \"issued\": {\n            \"date-parts\": [\n                [\n                    1998\n                ]\n            ]\n        },\n        \"DOI\": \"10.1002\\\/ana.410430517\",\n        \"PMID\": 9585363\n    },\n    {\n        \"id\": \"molgod-c49296f6c3df67c0c6f9832cd665d141\",\n        \"type\": \"article-journal\",\n        \"title\": \"7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide: a partial modulator of AMPA receptor desensitization devoid of neurotoxicity.\",\n        \"author\": [\n            {\n                \"family\": \"F\",\n                \"given\": \"Impagnatiello\"\n            },\n            {\n                \"family\": \"A\",\n                \"given\": \"Oberto\"\n            },\n            {\n                \"family\": \"al.\",\n                \"given\": \"Longone P et\"\n            }\n        ],\n        \"container-title\": \"Proceedings of the National Academy of Sciences of the United States of America\",\n        \"issued\": {\n            \"date-parts\": [\n                [\n                    1997\n                ]\n            ]\n        },\n        \"DOI\": \"10.1073\\\/pnas.94.13.7053\",\n        \"PMID\": 9192690,\n        \"URL\": \"https:\\\/\\\/pnas.org\\\/doi\\\/full\\\/10.1073\\\/pnas.94.13.7053\"\n    },\n    {\n        \"id\": \"molgod-ab9397fa2ee5572bc999b893967c60e0\",\n        \"type\": \"article-journal\",\n        \"title\": \"Effect of the AMPA receptor modulator IDRA 21 on LTP in hippocampal slices.\",\n        \"author\": [\n            {\n                \"family\": \"A\",\n                \"given\": \"Arai\"\n            },\n            {\n                \"family\": \"A\",\n                \"given\": \"Guidotti\"\n            },\n            {\n                \"family\": \"al.\",\n                \"given\": \"Costa E et\"\n            }\n        ],\n        \"container-title\": \"Neuroreport\",\n        \"issued\": {\n            \"date-parts\": [\n                [\n                    1996\n                ]\n            ]\n        },\n        \"DOI\": \"10.1097\\\/00001756-199609020-00031\",\n        \"PMID\": 8930991\n    },\n    {\n        \"id\": \"molgod-414e4547808dc51ab5571e752d4846e3\",\n        \"type\": \"article-journal\",\n        \"title\": \"Enantiomeric resolution with a new chiral stationary phase of 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide, a cognition-enhancing benzothiadiazine derivative.\",\n        \"author\": [\n            {\n                \"family\": \"DP\",\n                \"given\": \"Uzunov\"\n            },\n            {\n                \"family\": \"I\",\n                \"given\": \"Zivkovich\"\n            },\n            {\n                \"family\": \"al.\",\n                \"given\": \"Pirkle WH et\"\n            }\n        ],\n        \"container-title\": \"Journal of pharmaceutical sciences\",\n        \"issued\": {\n            \"date-parts\": [\n                [\n                    1995\n                ]\n            ]\n        },\n        \"DOI\": \"10.1002\\\/jps.2600840807\",\n        \"PMID\": 7500277\n    },\n    {\n        \"id\": \"molgod-774d08bfe8624de8f30bb6b85b3b2041\",\n        \"type\": \"article-journal\",\n        \"title\": \"5'-alkyl-benzothiadiazides: a new subgroup of AMPA receptor modulators with improved affinity.\",\n        \"author\": [\n            {\n                \"family\": \"D\",\n                \"given\": \"Phillips\"\n            },\n            {\n                \"family\": \"J\",\n                \"given\": \"Sonnenberg\"\n            },\n            {\n                \"family\": \"al.\",\n                \"given\": \"Arai AC et\"\n            }\n        ],\n        \"container-title\": \"Bioorganic & 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