AbbreviationsEuropejska umowa dot. międzynarodowego przewozu towarów niebezpiecznych, Oszacowanie toksyczności ostrej (Acute Toxicity Estimate), Chemical Abstracts Service, Classification, Labelling and Packaging (Rozp. 1272/2008), Rakotwórczość, mutagenność, toksyczność reprodukcyjna, Pochodny poziom niepowodujący zmian (Derived No-Effect Level), European Community number, Środki ochrony indywidualnej, Globalnie Zharmonizowany System (Globally Harmonized System), Międzynarodowe Zrzeszenie Transportu Lotniczego, Międzynarodowy kodeks morski towarów niebezpiecznych, Karta Charakterystyki (Safety Data Sheet), Stężenie śmiertelne 50% (Lethal Concentration), Dawka śmiertelna 50% (Lethal Dose), Najwyższe dopuszczalne stężenie (na stanowisku pracy), Chwilowe NDS, Occupational Exposure Limit, Trwałe, bioakumulacyjne i toksyczne, Przewidywane stężenie niepowodujące zmian (Predicted No-Effect Concentration), Registration, Evaluation, Authorisation and Restriction of Chemicals (Rozp. 1907/2006), Safety Data Sheet, Toksyczność narządowa (Specific Target Organ Toxicity), Substancja wzbudzająca szczególnie duże obawy (Substance of Very High Concern), Topological Polar Surface Area, Bardzo trwałe i bardzo bioakumulacyjne
Version historyv1, 28.04.2026, Pierwsza emisja. Auto-wygenerowane przez MOL-GOD v2.7.0.
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ReferencesPubChem, PubChem PUG REST API, https://pubchem.ncbi.nlm.nih.gov/compound/66981-73-5, Cache+consensus, Local cache (previously fetched), Local Cache, Local cache (previously fetched), ChEMBL (EBI), ChEMBL (EBI), Literature, literature
References chicago[1] PE i Rada. Rozp.(WE) nr 1907/2006 (REACH). Art.31, Zał.II. Dz.Urz.UE L 396/2006., [2] Komisja Europejska. Rozp.(UE) 2020/878 — zmiana Zał.II REACH. Dz.Urz.UE L 203/2020. Od 01.01.2023., [3] PE i Rada. Rozp.(WE) 1272/2008 (CLP)+ATP 19. Dz.Urz.UE L 353/2008., [4] United Nations. GHS Rev.9. ST/SG/AC.10/30/Rev.9. ONZ, 2021., [5] ISO. ISO 7010:2019 — Graphical symbols. Safety signs., [6] ISO. ISO 3864-1:2011 — Safety colours and safety signs., [7] PubChem. PubChem PUG REST API. URL: https://pubchem.ncbi.nlm.nih.gov/compound/66981-73-5 Data: ., [8] Cache+consensus. Local cache (previously fetched). Data: ., [9] Local Cache. Local cache (previously fetched). Data: ., [10] ChEMBL (EBI). ChEMBL (EBI). Data: ., [11] Literature. literature. Data: ., [12] Ustawa z 26.06.1974 r. — Kodeks pracy. Art.221–229. Dz.U. 2023 poz. 1465., [13] Rozp. MRiPS z 12.06.2018 r. — NDS/NDN. Dz.U. 2024 poz. 1017.
LiteratureThe neurobiological properties of tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation., et al., 2010, 10.1038/mp.2009.80, 19704408, 162, 1, https://europepmc.org/articles/PMC2902200?pdf=render, Tianeptine is a clinically used antidepressant that has drawn much attention, because this compound challenges traditional monoaminergic hypotheses of depression. It is now acknowledged that the antidepressant actions of tianeptine, together with its remarkable clinical tolerance, can be attributed , Europe PMC, 7, open, The Behavioral Effects of the Antidepressant Tianeptine Require the Mu-Opioid Receptor., et al., 2017, 10.1038/npp.2017.60, 28303899, 79, 1, https://www.nature.com/articles/npp201760.pdf, Depression is a debilitating chronic illness that affects around 350 million people worldwide. Current treatments, such as selective serotonin reuptake inhibitors, are not ideal because only a fraction of patients achieve remission. Tianeptine is an effective antidepressant with a previously unknown, Europe PMC, 6.85, open, Formulation of a novel tianeptine sodium orodispersible film., 2010, 10.1208/s12249-010-9464-2, 20532710, 67, 1, https://link.springer.com/content/pdf/10.1208/s12249-010-9464-2.pdf, The present investigation was undertaken with the objective of formulating orodispersible film(s) of the antidepressant drug tianeptine sodium to enhance the convenience and compliance by the elderly and pediatric patients. The novel film former, lycoat NG73 (granular hydroxypropyl starch), along wi, Europe PMC, 6.75, open, When an obscurity becomes trend: social-media descriptions of tianeptine use and associated atypical drug use., et al., 2021, 10.1080/00952990.2021.1904408, 33909525, 35, 1, https://www.ncbi.nlm.nih.gov/pmc/articles/8380661, <i>Background</i>: Originally believed to be an atypical antidepressant acting at serotonin transporters, tianeptine is now known to also be an atypical agonist at mu-opioid receptors. Its nonmedical use may be increasing amidst the broader context of novel drug and supplement use.<i>Objectives</i>:, Europe PMC, 6.33, open, Characteristics of Tianeptine Exposures Reported to the National Poison Data System - United States, 2000-2017., et al., 2018, 10.15585/mmwr.mm6730a2, 30070980, 31, 1, https://europepmc.org/articles/PMC6072055?pdf=render, Tianeptine (marketed as Coaxil or Stablon) is an atypical tricyclic drug used as an antidepressant in Europe, Asia, and Latin America. In the United States, tianeptine is not approved by the Food and Drug Administration (FDA) for medical use and is an unscheduled pharmaceutical agent* (1). Animal an, Europe PMC, 6.26, open, Long-term voluntary exercise and the mouse hypothalamic-pituitary-adrenocortical axis: impact of concurrent treatment with the antidepressant drug tianeptine., et al., 2006, 10.1111/j.1365-2826.2006.01489.x, 17076767, 52, We investigated whether voluntary exercise and concurrent antidepressant treatment (tianeptine; 20 mg/kg/day; 4 weeks) exert synergistic effects on the mouse hypothalamic-pituitary-adrenocortical (HPA) axis. Animals had access to a running wheel, were treated with the antidepressant, or received bot, Europe PMC, 6.09, paywall, Enhanced susceptibility to periodontitis in an animal model of depression: reversed by chronic treatment with the anti-depressant tianeptine., et al., 2006, 10.1111/j.1600-051x.2006.00935.x, 16820034, 46, <h4>Objective</h4>To test the hypothesis that the olfactory bulbectomy model of depression in rats could influence susceptibility to ligature-induced periodontitis, and that chronic treatment with the anti-depressant drug tianeptine could attenuate this effect.<h4>Material and methods</h4>Tianeptine, Europe PMC, 6.01, paywall, Tianeptine treatment induces antidepressive-like effects and alters BDNF and energy metabolism in the brain of rats., et al., 2012, 10.1016/j.bbr.2012.05.039, 22659397, 29, The present study was aimed at investigating the behavioral and molecular effects of tianeptine. To this aim, Wistar rats were treated with tianeptine (5, 10 and 15 mg/kg) or imipramine (30 mg/kg) acutely and chronically. The results showed that both treatments reduced the immobility time. The BDNF , Europe PMC, 5.72, paywall, The atypical antidepressant and neurorestorative agent tianeptine is a μ-opioid receptor agonist., et al., 2014, 10.1038/tp.2014.30, 25026323, 99, 1, https://europepmc.org/articles/PMC4119213?pdf=render, Current pharmacological treatments of depression and related disorders suffer from major problems, such as a low rate of response, slow onset of therapeutic effects, loss of efficacy over time and serious side effects. Therefore, there is an urgent need to explore new therapeutic approaches that add, Europe PMC, 5.5, open, Targeting the NLRP3 Inflammasome-Related Pathways via Tianeptine Treatment-Suppressed Microglia Polarization to the M1 Phenotype in Lipopolysaccharide-Stimulated Cultures., et al., 2018, 10.3390/ijms19071965, 29976873, 79, 1, https://www.mdpi.com/1422-0067/19/7/1965/pdf?version=1530776854, An increasing body of evidence postulates that microglia are the main mediators of inflammation-related disorders, including depression. Since activated microglia produce a wide range of pro- and anti-inflammatory factors, the modulation of M1/M2 microglial polarization by antidepressants may be cru, Europe PMC, 5.35, open
Nist linkhttps://webbook.nist.gov/cgi/cbook.cgi?ID=66981-73-5
Chembl idCHEMBL3659241
Wikidata qid
Chemspider url
Substance typeunknown
Grok description
Cross validationDane zweryfikowane z 4 źródeł (cache, pubchem, chembl, literature). Wykrytych konfliktów: 0.