AbbreviationsEuropejska umowa dot. międzynarodowego przewozu towarów niebezpiecznych, Oszacowanie toksyczności ostrej (Acute Toxicity Estimate), Chemical Abstracts Service, Classification, Labelling and Packaging (Rozp. 1272/2008), Rakotwórczość, mutagenność, toksyczność reprodukcyjna, Pochodny poziom niepowodujący zmian (Derived No-Effect Level), European Community number, Środki ochrony indywidualnej, Globalnie Zharmonizowany System (Globally Harmonized System), Międzynarodowe Zrzeszenie Transportu Lotniczego, Międzynarodowy kodeks morski towarów niebezpiecznych, Karta Charakterystyki (Safety Data Sheet), Stężenie śmiertelne 50% (Lethal Concentration), Dawka śmiertelna 50% (Lethal Dose), Najwyższe dopuszczalne stężenie (na stanowisku pracy), Chwilowe NDS, Occupational Exposure Limit, Trwałe, bioakumulacyjne i toksyczne, Przewidywane stężenie niepowodujące zmian (Predicted No-Effect Concentration), Registration, Evaluation, Authorisation and Restriction of Chemicals (Rozp. 1907/2006), Safety Data Sheet, Toksyczność narządowa (Specific Target Organ Toxicity), Substancja wzbudzająca szczególnie duże obawy (Substance of Very High Concern), Topological Polar Surface Area, Bardzo trwałe i bardzo bioakumulacyjne
Version historyv1, 28.04.2026, Pierwsza emisja. Auto-wygenerowane przez MOL-GOD v2.7.0.
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ReferencesPubChem, PubChem PUG REST API, https://pubchem.ncbi.nlm.nih.gov/compound/62613-82-5, Cache+consensus, Local cache (previously fetched), Local Cache, Local cache (previously fetched), ChEMBL (EBI), ChEMBL (EBI), Wikidata, wikidata, Literature, literature
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LiteraturePharmacokinetic-Pharmacodynamic and Response Sensitization Modeling of the Intraocular Pressure-Lowering Effect of the EP4 Agonist 5-{3-[(2S)-2-{(3R)-3-hydroxy-4-[3-(trifluoromethyl)phenyl]butyl}-5-oxopyrrolidin-1-yl]propyl}thiophene-2-carboxylate (PF-04475270), K. Luu, Eric Zhang, G. Prasanna et al., 2009, Journal of Pharmacology and Experimental Therapeutics, 10.1124/jpet.109.157800, 19690190, A preclinical population-based PD model suitable for capturing the time course of dog intraocular pressure (IOP) that exhibited time-dependent sensitization after topical administration of PF-04475270 may have general utility when PD sensitization is observed and is not a result of time- dependent PK., 10, 1, article, semantic_scholar, 3.06, paywall, Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor., G. Veinberg, M. Vorona, L. Zvejniece et al., 2013, Bioorganic & Medicinal Chemistry, 10.1016/j.bmc.2013.03.016, 23582449, Experiments with electrically stimulated rat vas deference contractions induced by the PRE-084, an agonist of sigma-1 receptor, showed that (4R,5S)- and 2-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamides with an R-configuration at the C-4 chiral centre in the 2-pyrrolidsone ring were more effective positive allosteric modulators of, 17, 0, 1, https://doi.org/10.7270/q2n87c5q, article, semantic_scholar, 2.88, open, One-pot synthesis of substituted pyrrolo[3,4-b]pyridine-4,5-diones based on the reaction of N-(1-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-2-oxo-2-arylethyl)acetamide with amines, V. G. Melekhina, A. Komogortsev, B. Lichitsky et al., 2019, Beilstein Journal of Organic Chemistry, 10.3762/bjoc.15.277, 31839829, The condensation of primary amines with N-(1-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-2-oxo-2-arylethyl)acetamides was explored. Thus, a previously unknown recyclization of the starting material was observed in acidic ethanol in the presence of an amine, which provided the corresponding dihydropyrro..., A practical and convenient one-pot synthetic method for substituted pyrrolo[3,4-b]pyridin-5-ones could be devised based on a previously unknown recyclization of the starting material in acidic ethanol in the presence of an amine., 4, 0, 1, https://www.beilstein-journals.org/bjoc/content/pdf/1860-5397-15-277.pdf, article, semantic_scholar, 2.05, open, Role of P-Glycoprotein and the Intestine in the Excretion of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide] in Rodents, C. Garner, E. Solon, Chii‐Ming Lai et al., 2008, Drug Metabolism And Disposition, 10.1124/dmd.107.017038, 18347085, The above data suggest that in the rodent the intestine serves as an organ of DPC 333 excretion, mediated in part by the transporter P-gp., 7, 0, article, semantic_scholar, 1.85, paywall, Studying the structure and evaluating α‐glucosidase inhibition of novel acetamide derivatives incorporating 4‐ethyl‐4H‐1,2,4‐triazole starting from 2‐(naphthalene‐1‐yl)acetic acid, Trong Duc Le, Tien Nguyen Cong, Thi-Minh-Dinh Tran et al., 2024, Asian Journal of Organic Chemistry, 10.1002/ajoc.202400063, 0, This research aims to create innovative compounds that incorporate 1,2,4‐triazole and exhibit α‐glucosidase inhibitory potential. Similar to our previously reported series of N‐aryl 2‐{[5‐(naphthalen‐1‐ylmethyl)‐4‐phenyl‐4H‐1,2,4‐triazol‐3‐yl]thio}acetamide compounds, we explore here 4‐ethyl instead..., 1, 0, 1, https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajoc.202400063, article, semantic_scholar, 1.45, open, Ethyl 2-(4-hydroxy-3-methoxyphenyl)-1-[3-(2-oxopyrrolidin-1-yl)propyl]-1H-benzimidazole-5-carboxylate monohydrate, Y. K. Yoon, M. A. Ali, T. S. Choon et al., 2011, Acta Crystallographica Section E, 10.1107/S1600536811052391, 22259586, In the title compound, C24H27N3O5·H2O, the essentially planar benzimidazole ring system [maximum deviation = 0.020 (1) Å] forms dihedral angles of 54.10 (11) and 67.79 (6)°, respectively, with the mean plane of pyrrolidin-2-one ring and the benzene ring. The pyrrolidin-2-one ring adopts an envelope ..., In the title compound, C24H27N3O5·H2O, the essentially planar benzimidazole ring system forms dihedral angles of 54.10 (11) and 67.79”(6)°, respectively, with the mean plane of pyrrolidin-2-one ring and the benzene ring., 1, 0, 1, https://journals.iucr.org/e/issues/2012/01/00/is5022/is5022.pdf, article, semantic_scholar, 1.45, open, Efficacy and safety of L-oxiracetam on cognitive function in patients with traumatic brain injury: a multicentre, randomised, double-blind, phase 3 clinical trial., Liu T, Wang J, Zhao Z et al., 2025, Signal transduction and targeted therapy, 10.1038/s41392-025-02492-5, 41381424, 0, 0, 1, https://www.nature.com/articles/s41392-025-02492-5.pdf, clinical-trial, pubmed, 1, open, Co-administration of Nanowired Oxiracetam and Neprilysin with Monoclonal Antibodies to Amyloid Beta Peptide and p-Tau Thwarted Exacerbation of Brain Pathology in Concussive Head Injury at Hot Environment., Nozari A, Sharma A, Wang Z et al., 2023, Advances in neurobiology, 10.1007/978-3-031-32997-5_7, 37480464, 0, 0, review, pubmed, 1, paywall, N-tert-Butyl-2-{2-[2-(4-chlorophenyl)-4-hydroxy-1-(5-methylisoxazol-3-yl)-5-oxo-2,5-dihydro-1H-pyrrol-3-yl]-N-(4-methoxyphenyl)acetamido}-2-(4-methoxyphenyl)acetamide methanol monosolvate: single-crystal X-ray diffraction study and Hirshfeld surface analysis, Mariia O Shyshkina, Yana I Sakhno, Oleksandr V Radchenko et al., 2021, Acta Crystallographica Section E: Crystallographic Communications, 10.1107/S2056989021011312, 34925883, The molecular and crystal structures of the title compound, C37H41ClN4O8, which has potential biological activity have been studied. This compound exists in the crystal phase as a methanol solvate...., 0, 0, 1, https://journals.iucr.org/e/issues/2021/12/00/zq2268/zq2268.pdf, article, semantic_scholar, 0.5, open, [Oxiracetam]., Gava R, Schifano F, 1989, Giornale di clinica medica, 2668093, 0, 0, clinical-trial, pubmed, 0, paywall
Nist linkhttps://webbook.nist.gov/cgi/cbook.cgi?ID=62613-82-5
Chembl idCHEMBL3644331
Wikidata qidQ415099
Chemspider url
Substance typeunknown
Grok description
Cross validationDane zweryfikowane z 5 źródeł (cache, pubchem, chembl, wikidata, literature). Wykrytych konfliktów: 0.