{"id":3894,"date":"2022-09-04T05:29:02","date_gmt":"2022-09-04T05:29:02","guid":{"rendered":"https:\/\/modafinil.pl\/?post_type=product&p=3894"},"modified":"2026-10-03T05:13:55","modified_gmt":"2026-10-03T05:13:55","slug":"flmodafinil","status":"publish","type":"product","link":"https:\/\/modafinil.pl\/en\/sklep\/flmodafinil\/","title":{"rendered":"Flmodafinil (CAS 90280-13-0) \u2014 Chemical Reagent 1000 mg, Purity \u2265 99%"},"content":{"rendered":"

2-[bis(4-fluorophenyl)methylsulfinyl]acetamide<\/strong>, crystalline powder, 1000 mg package. Material intended solely for in vitro laboratory and analytical research<\/strong>. The product is not intended for human or animal consumption<\/strong>, it is not a medicinal product, a dietary supplement, a foodstuff, or a cosmetic.<\/p>\n

Something That Needs to Be Said Upfront<\/h2>\n

Flmodafinil is in an unusual position: it is a compound that is well-defined chemically but almost absent from the peer-reviewed scientific literature<\/strong>. Searching the PubMed database under all of its names – flmodafinil, bisfluoromodafinil, lauflumide, CRL-40,940 – returns only a handful of entries<\/strong>, and these are analytical papers describing detection of the compound, not studies of the compound itself.<\/p>\n

We state this directly because it is relevant information for anyone planning to work with this material. There is no body of research to refer to.<\/strong> There are no clinical studies, no pharmacological reviews comparable to those existing for modafinil<\/a>, and no pharmacopoeial monograph. Everything that can be reliably stated concerns the molecule’s structure and its analytical behavior<\/strong> – and we limit this description to that.<\/p>\n

We treat this as a strength of the description, not a shortcoming. A page that attributed to this molecule properties documented for a different one would be misleading.<\/p>\n

Three Different Entities That Must Not Be Confused<\/h2>\n\n\n\n\n\n\n\n
Separating the layers: substance – medicinal product – reagent<\/caption>\n
Entity<\/th>\nWhat it is<\/th>\nStatus of flmodafinil<\/th>\n<\/tr>\n<\/thead>\n
Chemical substance
CAS 90280-13-0<\/th>\n		A chemical concept – a molecule with a defined structure, registered in databases (PubChem, ChemSpider).<\/td>\nyes<\/strong> – this is the only status this molecule actually has<\/td>\n<\/tr>\n
Medicinal product<\/th>\nA pharmaceutical preparation: a defined formulation, GMP regime, registration documentation, oversight.<\/td>\nNO – in any country.<\/strong> Unlike modafinil, flmodafinil has never been registered as a drug<\/strong><\/td>\n<\/tr>\n
Chemical reagent
the material offered here<\/th>\n		Material for laboratory and analytical work.<\/td>\nyes<\/strong> – and it is offered solely in this capacity<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

This distinction matters more here than it does for modafinil. In that case a real medicinal product exists, from which the reagent must be distinguished. Here there is nothing to confuse with a drug, because no drug exists<\/strong> – no registered form of this substance intended for human use exists in any jurisdiction.<\/p>\n

Reagent Identification Card<\/h2>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Registry data and identifiers – flmodafinil<\/caption>\n
Systematic name (IUPAC)<\/th>\n2-[bis(4-fluorophenyl)methylsulfinyl]acetamide<\/td>\n<\/tr>\n
Common names<\/th>\nflmodafinil, bisfluoromodafinil, lauflumide<\/td>\n<\/tr>\n
Development code<\/th>\nCRL-40,940<\/td>\n<\/tr>\n
CAS Number<\/th>\n90280-13-0<\/td>\n<\/tr>\n
Molecular formula<\/th>\nC15<\/sub>H13<\/sub>F2<\/sub>NO2<\/sub>S<\/td>\n<\/tr>\n
Molar mass<\/th>\n309.33 g\u00b7mol-1<\/sup><\/td>\n<\/tr>\n
Monoisotopic mass<\/th>\n309.0635 Da<\/td>\n<\/tr>\n
InChIKey<\/th>\nYEAQNUMCWMRYMU-UHFFFAOYSA-N<\/td>\n<\/tr>\n
SMILES<\/th>\nC1=CC(=CC=C1C(C2=CC=C(C=C2)F)S(=O)CC(=O)N)F<\/td>\n<\/tr>\n
PubChem CID<\/th>\n13271852<\/a><\/td>\n<\/tr>\n
Form<\/th>\ncrystalline powder, white to off-white<\/td>\n<\/tr>\n
Purity<\/th>\n\u2265 99%<\/td>\n<\/tr>\n
Intended use<\/th>\nresearch reagent – not for human or animal consumption<\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

What the Two Fluorine Atoms Do<\/h2>\n

Flmodafinil differs from modafinil by two atoms<\/strong>. The core is identical – a benzhydrylsulfinyl group terminating in an amide – and the modification consists of introducing a fluorine atom at the para position of each of the two phenyl rings<\/strong>. Hence the common name “bisfluoromodafinil”: fluorine twice over.<\/p>\n

Measurable Effects, Not Assumed Ones<\/h3>\n

Para-fluorine substitution is one of the most common modifications in medicinal chemistry and has predictable physicochemical consequences<\/strong> that can be stated without reference to any biological studies:<\/p>\n\n\n\n\n\n\n\n\n\n\n
Comparison of descriptors: modafinil versus flmodafinil<\/caption>\n
Parameter<\/th>\nModafinil<\/th>\nFlmodafinil<\/th>\nSignificance<\/th>\n<\/tr>\n<\/thead>\n
Molecular formula<\/th>\nC15<\/sub>H15<\/sub>NO2<\/sub>S<\/td>\nC15<\/sub>H13<\/sub>F2<\/sub>NO2<\/sub>S<\/td>\ndifference: 2\u00d7H \u2192 2\u00d7F<\/td>\n<\/tr>\n
Molar mass<\/th>\n273.35<\/td>\n309.33<\/strong><\/td>\n+35.98 – easy differentiation by MS<\/td>\n<\/tr>\n
XLogP<\/th>\n\u2248 1.3<\/td>\n\u2248 1.9<\/strong><\/td>\nhigher lipophilicity \u2192 later elution in RP-HPLC<\/td>\n<\/tr>\n
Polar surface area (TPSA)<\/th>\n71.7 \u00c52<\/sup><\/td>\n79.4 \u00c52<\/sup><\/td>\nsimilar – fluorine does not change the hydrogen-bonding profile<\/td>\n<\/tr>\n
Hydrogen bond acceptors<\/th>\n3<\/td>\n5<\/td>\nthe two fluorine atoms are counted as acceptors<\/td>\n<\/tr>\n
Rotatable bonds<\/th>\n5<\/td>\n5<\/td>\nunchanged – fluorine adds no conformational freedom<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Why This Matters for the Laboratory<\/h3>\n

The 36 Da mass difference<\/strong> makes distinguishing the two compounds in mass spectrometry trivial – no chromatographic separation is required, the ion mass alone suffices. This is the opposite situation to isomeric pairs, where mass settles nothing.<\/p>\n

Fluorine does not produce a characteristic isotope pattern.<\/strong> Unlike bromine (two stable isotopes in roughly a 1:1 ratio, as in bromantan<\/a>), fluorine is practically monoisotopic – 19<\/sup>F accounts for almost 100% of its natural abundance. The presence of fluorine therefore cannot be recognized from an isotope cluster<\/strong>; it must be inferred from the exact mass or confirmed by 19<\/sup>F NMR, a technique for which this compound is a gratifying subject – the two equivalent fluorine atoms give a single, clean signal.<\/p>\n

Stereogenic Center<\/h3>\n

As in modafinil, the sulfur atom in the sulfoxide group carries four different substituents and is a stereogenic center<\/strong>. The symmetrical fluorine substitution on both rings does not eliminate<\/strong> this chirality – the two rings remain equivalent to each other, but the sulfur still carries four different substituents. The material should therefore be treated as a mixture of enantiomers unless the declaration states otherwise.<\/p>\n

Nomenclature: Four Names, One Compound<\/h2>\n