{"id":1273,"date":"2023-09-11T11:31:45","date_gmt":"2023-09-11T11:31:45","guid":{"rendered":"https:\/\/modafinil.pl\/?post_type=product&p=1273"},"modified":"2025-09-07T02:24:52","modified_gmt":"2025-09-07T02:24:52","slug":"5-htp","status":"publish","type":"product","link":"https:\/\/modafinil.pl\/en\/sklep\/5-htp\/","title":{"rendered":"5-HTP, czysto\u015b\u0107 \u2265 99.00% NONSENSIA LAB – 1000mg"},"content":{"rendered":"

5-HTP (5-Hydroxytryptophan) <\/span><\/span><\/strong><\/h1>\n

 <\/p>\n

\u00a0High Purity Chemical Reagent | CAS 56-69-9<\/span><\/span><\/strong><\/p>\n

Product Specifications<\/span><\/span><\/strong><\/p>\n

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    Chemical name:<\/span><\/span><\/strong> \u00a05-Hydroxytryptophan (5-HTP)<\/span><\/span><\/p>\n<\/li>\n

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    Synonyms:<\/span><\/span><\/strong> \u00a0Oxitriptan; L-5-HTP; 2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid<\/span><\/span><\/p>\n<\/li>\n

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    CAS number:<\/span><\/span><\/strong> \u00a056-69-9<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Molecular formula:<\/span><\/span><\/strong> \u00a0C\u2081\u2081H\u2081\u2082N\u2082O\u2083<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Molar mass:<\/span><\/span><\/strong> \u00a0220.23 g\u00b7mol\u207b\u00b9<\/span><\/span><\/p>\n<\/li>\n

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    Purity:<\/span><\/span><\/strong> \u00a0\u2265 99.00%<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Net weight per package:<\/span><\/span><\/strong> \u00a01000 mg<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Appearance:<\/span><\/span><\/strong> \u00a0White to cream, fine crystalline powder<\/span><\/span><\/p>\n<\/li>\n

  • \n

    Packaging:<\/span><\/span><\/strong> Sealed aluminum foil zip-lock bag.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

    Comprehensive Chemical and Biological Profile<\/span><\/span><\/strong><\/p>\n

    5-Hydroxytryptophan (5-HTP) is an extremely important monoamine compound that holds a key position in human biochemistry as the direct precursor to the neurotransmitter serotonin (5-hydroxytryptamine or 5-HT). It is biosynthesized endogenously from the essential amino acid L-tryptophan by the enzyme tryptophan hydroxylase (TPH), which catalyzes the rate-limiting step in serotonin synthesis. This conversion is a fundamental bottleneck in the production of serotonin and, consequently, its metabolite, the sleep-regulating melatonin.<\/span><\/span><\/p>\n

    Although it occurs in trace amounts in some foods (e.g., turkey, bananas), the primary commercial source for extracting high-quality 5-HTP is the seeds of the African shrub Griffonia simplicifolia. The 5-HTP molecule is characterized by an indole ring system with a hydroxyl group at the 5-position and an alanine side chain, making it a polar, water-soluble compound.<\/span><\/span><\/p>\n

    A key pharmacokinetic property of 5-HTP is its ability to effectively cross the blood-brain barrier, unlike serotonin itself. Upon reaching the central nervous system, it is rapidly decarboxylated to serotonin by the enzyme aromatic L-amino acid decarboxylase (AADC), a process that requires vitamin B6 as a cofactor. This direct biosynthetic pathway underlies its profound effects on serotonergic systems in research settings.<\/span><\/span><\/p>\n

    Research Applications and Potential Mechanisms<\/span><\/span><\/strong><\/p>\n

    This high-purity 5-HTP is intended for controlled in vitro and animal model studies designed to study the broad serotonergic system. Its scientific applications are multifaceted:<\/span><\/span><\/p>\n

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      Neuropharmacological Research:<\/span><\/span><\/strong> \u00a0Used to study the biosynthesis, release, reuptake, and receptor interactions of serotonin (5-HT\u2081 to 5-HT\u2087 receptor families). Research explores its potential role in modulating mood, anxiety, reward processing, learning, and memory via serotonergic pathways.<\/span><\/span><\/p>\n<\/li>\n

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      Sleep and Circadian Rhythm Research:<\/span><\/span><\/strong> \u00a0As a precursor to melatonin, 5-HTP is a key tool for studying the regulation of the sleep-wake cycle and disorders such as insomnia.<\/span><\/span><\/p>\n<\/li>\n

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      Metabolism and Appetite Regulation Research:<\/span><\/span><\/strong> \u00a0Research is using 5-HTP to investigate the role of serotonin in satiety signaling, eating behavior, and energy homeostasis, which has implications for understanding obesity.<\/span><\/span><\/p>\n<\/li>\n

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      Models of Pain Perception and Fibromyalgia:<\/span><\/span><\/strong> \u00a0Preliminary studies in animal models suggest potential modulatory effects on pain pathways, providing a basis for studying conditions such as fibromyalgia.<\/span><\/span><\/p>\n<\/li>\n

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      Drug Interaction and Toxicology Studies:<\/span><\/span><\/strong> \u00a0Essential for investigating pharmacokinetic interactions, particularly the risk of serotonin toxicity in combination with other serotonergic agents.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

      Analytical Methods and Quality Assurance<\/span><\/span><\/strong><\/p>\n

      Our product undergoes rigorous quality control to ensure \u226599.00% purity and the absence of significant impurities such as L-tryptophan, which has historically been linked to eosinophilia-myalgia syndrome (EMS). Advanced analytical techniques are used:<\/span><\/span><\/p>\n

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      • \n

        High Performance Liquid Chromatography (HPLC)<\/span><\/span><\/strong> \u00a0coupled with diode array detectors (DAD) or mass spectrometers (MS) for precise quantification.<\/span><\/span><\/p>\n<\/li>\n

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        Raman Spectroscopy:<\/span><\/span><\/strong> \u00a0Identifies characteristic peaks (e.g., ~1356 cm\u207b\u00b9) for structural verification and purity assessment.<\/span><\/span><\/p>\n<\/li>\n

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        Terahertz Time-Domain Spectroscopy (THz-TDS):<\/span><\/span><\/strong> \u00a0A non-destructive method used to detect specific THz absorption fingerprints (e.g., 1.14 THz for 5-HTP) and identify potential contaminants.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

        All batches are tested for heavy metals and microbiological contamination, ensuring that rigorous quality standards for research reagents are met.<\/span><\/span><\/p>\n

        Critical Safety and Handling Information<\/span><\/span><\/strong><\/p>\n

        \u2757 THIS PRODUCT IS INTENDED FOR LABORATORY SCIENTIFIC RESEARCH BY QUALIFIED PERSONNEL ONLY. IT IS NOT INTENDED FOR DIAGNOSTIC, THERAPEUTIC, OR RECREATIONAL USE IN HUMANS OR ANIMALS. IT IS NOT A DIETARY SUPPLEMENT AND SHOULD NEVER BE CONSUMED.<\/span><\/span><\/p>\n

        The most serious risk associated with the pharmacological use of 5-HTP is\u00a0 <\/span><\/span>Serotonin Syndrome (SS)<\/span><\/span><\/strong> , a potentially life-threatening condition caused by excessive serotonergic activity in the central nervous system.<\/span><\/span><\/p>\n

        Symptoms of Serotonin Syndrome include:<\/span><\/span><\/strong><\/p>\n

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          Agitation, anxiety, confusion<\/span><\/span><\/p>\n<\/li>\n

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          Excessive sweating (hyperhidrosis)<\/span><\/span><\/p>\n<\/li>\n

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          Tachycardia (rapid heart rate) and hypertension<\/span><\/span><\/p>\n<\/li>\n

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          Hyperthermia (high body temperature)<\/span><\/span><\/p>\n<\/li>\n

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          Excessive reflex response (hyperreflexia) and muscle stiffness<\/span><\/span><\/p>\n<\/li>\n

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          Tremors, myoclonus (muscle jerks)<\/span><\/span><\/p>\n<\/li>\n

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          Diarrhea<\/span><\/span><\/p>\n<\/li>\n

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          In severe cases: convulsions, loss of consciousness and death.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

          Potentially Dangerous Interactions:<\/span><\/span><\/strong> \u00a0Extreme caution should be used to avoid concomitant exposure with other serotonergic agents, including:<\/span><\/span><\/p>\n

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          • \n

            Antidepressants:<\/span><\/span><\/strong> \u00a0SSRIs (e.g. fluoxetine), SNRIs, TCAs, MAOIs.<\/span><\/span><\/p>\n<\/li>\n

          • \n

            Other compounds:<\/span><\/span><\/strong> \u00a0Tryptophan, St. John’s wort, S-adenosylmethionine (SAM-e), some opioids (e.g., tramadol), antiemetics (e.g., ondansetron), and illegal substances (e.g., MDMA, DMT).<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

            Note to Researchers:<\/span><\/span><\/strong> \u00a0Administration of high doses of 5-HTP in rodent models elicits a head-twitch response (a behavioral indicator of psychedelic effects), potentially mediated by the 5-HT\u2082A receptor following metabolic conversion to active metabolites. This highlights the complex psychopharmacology of 5-HTP and the need for controlled laboratory studies.<\/span><\/span><\/p>\n

            Storage and Processing<\/span><\/span><\/strong><\/p>\n

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            • \n

              Storage:<\/span><\/span><\/strong> \u00a0Store in a cool, dry, and well-ventilated place. Store in a tightly closed container, protected from light and moisture. For maximum shelf life, long-term storage at -20\u00b0C is recommended.<\/span><\/span><\/p>\n<\/li>\n

            • \n

              Handling:<\/span><\/span><\/strong> \u00a0Personnel must wear appropriate protective clothing (PPE), including gloves, safety glasses, and a lab coat. Avoid inhaling dust. Use only in a fume hood or well-ventilated area.<\/span><\/span><\/p>\n<\/li>\n

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              Disposal:<\/span><\/span><\/strong> \u00a0Dispose of waste in accordance with all applicable local, state and federal regulations regarding chemical waste.<\/span><\/span><\/p>\n<\/li>\n<\/ul>\n

              Selected Scientific References<\/span><\/span><\/strong><\/p>\n

                \n
              1. \n

                Turner, E. H., Loftis, J. M., & Blackwell, A. D. (2006). Serotonin a la carte: supplementation with the serotonin precursor 5-hydroxytryptophan. Pharmacology & Therapeutics, 109(3), 325\u2013338.<\/span><\/span><\/p>\n<\/li>\n

              2. \n

                Jangid, P., Malik, P., Singh, P., Sharma, M., & Gulia, A. K. (2013). Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode. Asian Journal of Psychiatry, 6(1), 29\u201334.<\/span><\/span><\/p>\n<\/li>\n

              3. \n

                Ceci, F., Cangiano, C., Cairella, M., Cascino, A., Del Ben, M., Muscaritoli, M., … & Rossi Fanelli, F. (1989). The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects. Journal of Neural Transmission, 76(2), 109\u2013117.<\/span><\/span><\/p>\n<\/li>\n

              4. \n

                Birdsall, T. C. (1998). 5-Hydroxytryptophan: a clinically-effective serotonin precursor. Alternative Medicine Review, 3(4), 271\u2013280.<\/span><\/span><\/p>\n<\/li>\n

              5. \n

                Shaw, K., Turner, J., & Del Mar, C. (2002). Tryptophan and 5-hydroxytryptophan for depression. Cochrane Database of Systematic Reviews, (1), CD003198.<\/span><\/span><\/p>\n<\/li>\n<\/ol>\n

                Legal Disclaimer<\/span><\/span><\/strong><\/p>\n

                This product is sold for laboratory research and development purposes only. It is not classified or intended for use as a drug, food additive, dietary supplement, or for any form of human consumption. The buyer assumes full responsibility for safe handling, storage, and disposal in accordance with their institution’s guidelines and all applicable laws. Not for diagnostic or therapeutic use.<\/span><\/span><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

                5-HTP (5-Hydroxytryptophan) – Natural Serotonin Precursor<\/span><\/span><\/strong><\/p>\n

                Lift your mood, improve sleep quality, and support your emotional well-being with 5-HTP! Our product is pure 5-HTP with over 99% purity, providing 1,000 mg per serving. 5-HTP is a natural precursor to serotonin, affecting mood, appetite, and sleep. It positively impacts behavior and nervous system function. We caution against using it with caution in combination with other medications that affect serotonin. Choose quality and well-being with our 5-HTP!<\/span><\/span><\/p>\n","protected":false},"featured_media":1287,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[270],"product_tag":[296,382,381,297,298],"class_list":{"0":"post-1273","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-natural","7":"product_tag-5-htp","8":"product_tag-chno","9":"product_tag-cas-number-56-69-9","10":"product_tag-serotonina","11":"product_tag-serotonine","13":"first","14":"instock","15":"shipping-taxable","16":"purchasable","17":"product-type-simple"},"yoast_head":"\n5-HTP, czysto\u015b\u0107 \u2265 99.00% NONSENSIA LAB - 1000mg - NONSENSIA, Laboratorium.<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/modafinil.pl\/en\/sklep\/5-htp\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"5-HTP, czysto\u015b\u0107 \u2265 99.00% NONSENSIA LAB - 1000mg - NONSENSIA, Laboratorium.\" \/>\n<meta property=\"og:description\" content=\"5-HTP (5-Hydroxytryptophan) - Natural Serotonin Precursor Lift your mood, improve sleep quality, and support your emotional well-being with 5-HTP! Our product is pure 5-HTP with over 99% purity, providing 1,000 mg per serving. 5-HTP is a natural precursor to serotonin, affecting mood, appetite, and sleep. It positively impacts behavior and nervous system function. We caution against using it with caution in combination with other medications that affect serotonin. Choose quality and well-being with our 5-HTP!\" \/>\n<meta property=\"og:url\" content=\"https:\/\/modafinil.pl\/en\/sklep\/5-htp\/\" \/>\n<meta property=\"og:site_name\" content=\"NONSENSIA, Laboratorium.\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-07T02:24:52+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/modafinil.pl\/wp-content\/uploads\/2023\/09\/5-HTP-Supplement.jpg.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1280\" \/>\n\t<meta property=\"og:image:height\" content=\"896\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/modafinil.pl\/en\/sklep\/5-htp\/\",\"url\":\"https:\/\/modafinil.pl\/en\/sklep\/5-htp\/\",\"name\":\"5-HTP, czysto\u015b\u0107 \u2265 99.00% NONSENSIA LAB - 1000mg - NONSENSIA, Laboratorium.\",\"isPartOf\":{\"@id\":\"https:\/\/modafinil.pl\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/modafinil.pl\/en\/sklep\/5-htp\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/modafinil.pl\/en\/sklep\/5-htp\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/modafinil.pl\/wp-content\/uploads\/2023\/09\/5-HTP-Supplement.jpg.jpg\",\"datePublished\":\"2023-09-11T11:31:45+00:00\",\"dateModified\":\"2025-09-07T02:24:52+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/modafinil.pl\/en\/sklep\/5-htp\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/modafinil.pl\/en\/sklep\/5-htp\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/modafinil.pl\/en\/sklep\/5-htp\/#primaryimage\",\"url\":\"https:\/\/modafinil.pl\/wp-content\/uploads\/2023\/09\/5-HTP-Supplement.jpg.jpg\",\"contentUrl\":\"https:\/\/modafinil.pl\/wp-content\/uploads\/2023\/09\/5-HTP-Supplement.jpg.jpg\",\"width\":1280,\"height\":896,\"caption\":\"5-htp\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/modafinil.pl\/en\/sklep\/5-htp\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/modafinil.pl\/en\/shop-2\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Nonsensia .: LAB\",\"item\":\"https:\/\/modafinil.pl\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"5-HTP, czysto\u015b\u0107 \u2265 99.00% NONSENSIA LAB – 1000mg\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/modafinil.pl\/#website\",\"url\":\"https:\/\/modafinil.pl\/\",\"name\":\"NONSENSIA, Laboratorium.\",\"description\":\"Modafinil, Bromantane NOOTROPIKI. 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Our product is pure 5-HTP with over 99% purity, providing 1,000 mg per serving. 5-HTP is a natural precursor to serotonin, affecting mood, appetite, and sleep. It positively impacts behavior and nervous system function. We caution against using it with caution in combination with other medications that affect serotonin. 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