{"id":4022,"date":"2026-10-27T07:00:00","date_gmt":"2026-10-27T06:00:00","guid":{"rendered":"https:\/\/modafinil.pl\/?p=4022"},"modified":"2026-10-08T14:12:06","modified_gmt":"2026-10-08T12:12:06","slug":"didesoxymodafinil-what-removing-two-oxygen-atoms-means","status":"publish","type":"post","link":"https:\/\/modafinil.pl\/en\/didesoxymodafinil-what-removing-two-oxygen-atoms-means\/","title":{"rendered":"Didesoxymodafinil: What Removing Two Oxygen Atoms Means"},"content":{"rendered":"<p><strong>The prefix &#8220;dides\u00adoxy&#8221; in a compound&#8217;s name means exactly this: two oxygen atoms have been removed.<\/strong> It sounds like a detail: two atoms in a molecule that contains several dozen. In practice, removing oxygen from a specific position can change polarity, stability, and chromatographic behavior. In this case, it also changes the number of stereogenic centers in the molecule.<\/p>\n<p>The most important point for evaluating this text should be stated up front: <strong>there is practically no literature devoted directly to this compound<\/strong>. What follows is derived from functional-group chemistry and from work on the parent molecule and on series of its analogues. For each of these sources, we indicate what it concerns. <a href=\"https:\/\/modafinil.pl\/en\/sklep\/modana-didesoxymodafinil\/\">Modana, CAS number 15515-59-0<\/a>, is offered by us as a chemical reagent.<\/p>\n<h2>Identity card<\/h2>\n<p class=\"ns-nota-danych\">The values in the table come from the PubChem database (record CID <a href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/279413\" rel=\"nofollow noopener\" target=\"_blank\">279413<\/a>), as of 2026-09-08. We give the date because database entries are sometimes updated, and a number without information on when it was retrieved goes out of date without anyone noticing.<\/p>\n<table class=\"ns-karta\">\n<tbody>\n<tr>\n<th scope=\"row\">CAS number<\/th>\n<td>15515-59-0<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular formula<\/th>\n<td>C<sub>15<\/sub>H<sub>17<\/sub>NS<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molar mass<\/th>\n<td>243.4 g\/mol<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Systematic name<\/th>\n<td>2-benzhydrylsulfanylethanamine<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">InChIKey<\/th>\n<td><code>BIPNUYXEYOEPHN-UHFFFAOYSA-N<\/code><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">SMILES<\/th>\n<td><code>C1=CC=C(C=C1)C(C2=CC=CC=C2)SCCN<\/code><\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Partition coefficient (logP)<\/th>\n<td>3.1<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Topological polar surface area<\/th>\n<td>51.3 \u00c5\u00b2<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Hydrogen bond donors \/ acceptors<\/th>\n<td>1 \/ 2<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Sulfoxide and sulfide: what the difference is<\/h2>\n<p>In the parent molecule, the sulfur atom is in an oxidized form: it is double-bonded to oxygen, forming a sulfoxide group. Removing this oxygen converts the sulfoxide group into a sulfide, which is sulfur bonded only to two carbon residues.<\/p>\n<p>This substitution has several consequences that are well established in organic chemistry and do not require separate studies of the specific compound.<\/p>\n<p><strong>Polarity drops markedly.<\/strong> The sulfoxide group is strongly polar, because the sulfur\u2013oxygen bond has a large dipole moment. A sulfide is much less polar. The practical result is a change in solubility, and in reversed-phase chromatography the compound is retained longer.<\/p>\n<p><strong>The stereogenic center at sulfur disappears.<\/strong> This is the most interesting consequence. In a sulfoxide, the sulfur atom has four different substituents (two carbon residues, oxygen, and a lone electron pair) and is a stereogenic center. For this reason, the parent molecule exists as a pair of enantiomers, and one of them is sometimes studied separately; it has been described as an inhibitor with a profile that departs from the classical pattern.<sup class=\"ns-cyt\"><a href=\"#zrodlo-1\">1<\/a><\/sup> In the sulfide there is no oxygen, there are three substituents, and the stereocenter at sulfur disappears. The molecule no longer exists as a pair of enantiomers that differ in configuration at this atom.<\/p>\n<p><strong>Susceptibility to oxidation increases.<\/strong> Sulfides are oxidized to sulfoxides relatively easily, by atmospheric oxygen, in the presence of light, or by traces of metals or peroxides in solvents. This is the reverse of the direction in which the molecule was obtained, and it has direct implications for storage.<\/p>\n<h2>Why none of this says anything about activity<\/h2>\n<p>It is tempting to assume that because the scaffold stayed the same, the properties will be similar. The literature on this family says the opposite, and says it emphatically.<\/p>\n<p>An analysis published in 2024 described the structural basis of the activity cliff in a group of dopamine transporter inhibitors based on the parent molecule. An activity cliff is a situation in which a small structural change produces a disproportionately large change in properties.<sup class=\"ns-cyt\"><a href=\"#zrodlo-2\">2<\/a><\/sup> Earlier work on series of analogues, both heterocyclic<sup class=\"ns-cyt\"><a href=\"#zrodlo-3\">3<\/a><\/sup> and thiazole-based,<sup class=\"ns-cyt\"><a href=\"#zrodlo-4\">4<\/a><\/sup> showed the same thing empirically: structure\u2013activity relationships in this group are not smooth.<\/p>\n<p>It is also worth noting that the way the parent molecule interacts with its molecular target turned out to differ from the pattern typical of its class.<sup class=\"ns-cyt\"><a href=\"#zrodlo-5\">5<\/a><\/sup> The first affinity measurement, made in 1994, gave a low value and for years undermined the whole hypothesis.<sup class=\"ns-cyt\"><a href=\"#zrodlo-6\">6<\/a><\/sup> The history of this family is therefore a history of conclusions that had to be revised several times.<\/p>\n<p>In other words, here in particular, extrapolating from similarity of structural formula is especially unreliable. The parent molecule has its own extensive literature, including summaries of its pharmacokinetic and pharmacodynamic properties.<sup class=\"ns-cyt\"><a href=\"#zrodlo-7\">7<\/a><\/sup> The history of the dispute over its mechanism is instructive in itself, and we describe it in our article on <a href=\"https:\/\/modafinil.pl\/modafinil-a-transporter-dopaminy-co-wykazaly-badania-obrazowe\/\">what imaging studies have shown<\/a>. None of this carries over automatically to the derivative lacking the oxygen.<\/p>\n<h2>Practical consequences for the material<\/h2>\n<p>Since the pharmacological literature is silent, what follows from the chemistry is what matters. Here it tells us a good deal, and the knowledge is useful.<\/p>\n<p><strong>Storage.<\/strong> The susceptibility of sulfides to oxidation means that the material should be kept away from oxygen and light, preferably in a tightly sealed container, in a cool place. Oxidation does not destroy the molecule. It converts it into a different compound, which is more dangerous, because the product is not an obvious &#8220;decomposition&#8221; but a different substance.<\/p>\n<p><strong>Identity control.<\/strong> A proton spectrum distinguishes a sulfide from a sulfoxide, because the protons adjacent to sulfur resonate at a different position depending on its oxidation state. This is one of those distinctions that are visible in the spectrum immediately. We explain why a spectrum can be stronger evidence of identity than a chromatogram in our article on <a href=\"https:\/\/modafinil.pl\/en\/proton-nmr-spectrum-as-proof-of-substance-identity\/\">the proton spectrum as evidence of identity<\/a>.<\/p>\n<p><strong>Interpreting the chromatogram.<\/strong> If a peak with a shorter retention time than the main peak appears in the material, then in a reversed-phase system the natural suspect is the oxidation product, which is more polar and therefore less strongly retained. This hypothesis is worth checking first, before turning to more exotic explanations.<\/p>\n<h2>A note on nomenclature<\/h2>\n<p>Compounds in this family are known by many names at once: systematic, common, trade, and code names. When searching the literature, this is a real obstacle. The same compound may be described under three different terms, and searching for just one of them gives a falsely sparse picture.<\/p>\n<p>For this reason, with compounds that have little literature, it is always worth starting from the CAS number rather than the name. The number identifies a specific compound unambiguously and does not depend on naming conventions. We describe separately what a CAS number identifies and what it does not guarantee, because it too has limitations worth being aware of.<\/p>\n<p>For someone working with such material, the practical conclusion is this. With a compound that has no direct literature, confirming identity yourself and storing the material carefully matter more, because there is no external dataset against which observations could be compared. We describe how to read the document supplied with the material in our article on the <a href=\"https:\/\/modafinil.pl\/en\/how-to-read-a-certificate-of-analysis-coa-for-a-chemical-reagent\/\">certificate of analysis<\/a>.<\/p>\n<h2>Sources<\/h2>\n<p class=\"ns-zrodla-nota\">Each item below was retrieved from the PubMed database through the E-utilities interface and is not reproduced from memory. The PMID numbers link to the source records.<\/p>\n<ol class=\"ns-zrodla\">\n<li id=\"zrodlo-1\">Loland CJ, Mereu M, Okunola OM et al. <em>R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse<\/em>. Biol Psychiatry. 2012;72:405-13. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22537794\/\" rel=\"nofollow noopener\" target=\"_blank\">22537794<\/a>. DOI: <a href=\"https:\/\/doi.org\/10.1016\/j.biopsych.2012.03.022\" rel=\"nofollow noopener\" target=\"_blank\">10.1016\/j.biopsych.2012.03.022<\/a>.<\/li>\n<li id=\"zrodlo-2\">Lee KH, Camacho-Hernandez GA, Newman AH et al. <em>The Structural Basis of the Activity Cliff in Modafinil-Based Dopamine Transporter Inhibitors<\/em>. Biomolecules. 2024;14. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38927116\/\" rel=\"nofollow noopener\" target=\"_blank\">38927116<\/a>. DOI: <a href=\"https:\/\/doi.org\/10.3390\/biom14060713\" rel=\"nofollow noopener\" target=\"_blank\">10.3390\/biom14060713<\/a>.<\/li>\n<li id=\"zrodlo-3\">Kalaba P, Aher NY, Ili\u0107 M et al. <em>Heterocyclic Analogues of Modafinil as Novel, Atypical Dopamine Transporter Inhibitors<\/em>. J Med Chem. 2017;60:9330-9348. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29091428\/\" rel=\"nofollow noopener\" target=\"_blank\">29091428<\/a>. DOI: <a href=\"https:\/\/doi.org\/10.1021\/acs.jmedchem.7b01313\" rel=\"nofollow noopener\" target=\"_blank\">10.1021\/acs.jmedchem.7b01313<\/a>.<\/li>\n<li id=\"zrodlo-4\">Kalaba P, Ili\u0107 M, Aher NY et al. <em>Structure-Activity Relationships of Novel Thiazole-Based Modafinil Analogues Acting at Monoamine Transporters<\/em>. J Med Chem. 2020;63:391-417. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31841637\/\" rel=\"nofollow noopener\" target=\"_blank\">31841637<\/a>. DOI: <a href=\"https:\/\/doi.org\/10.1021\/acs.jmedchem.9b01938\" rel=\"nofollow noopener\" target=\"_blank\">10.1021\/acs.jmedchem.9b01938<\/a>.<\/li>\n<li id=\"zrodlo-5\">Schmitt KC, Reith ME. <em>The atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitors<\/em>. PLoS One. 2011;6:e25790. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22043293\/\" rel=\"nofollow noopener\" target=\"_blank\">22043293<\/a>. DOI: <a href=\"https:\/\/doi.org\/10.1371\/journal.pone.0025790\" rel=\"nofollow noopener\" target=\"_blank\">10.1371\/journal.pone.0025790<\/a>.<\/li>\n<li id=\"zrodlo-6\">Mignot E, Nishino S, Guilleminault C et al. <em>Modafinil binds to the dopamine uptake carrier site with low affinity<\/em>. Sleep. 1994;17:436-7. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/7991954\/\" rel=\"nofollow noopener\" target=\"_blank\">7991954<\/a>. DOI: <a href=\"https:\/\/doi.org\/10.1093\/sleep\/17.5.436\" rel=\"nofollow noopener\" target=\"_blank\">10.1093\/sleep\/17.5.436<\/a>.<\/li>\n<li id=\"zrodlo-7\">Sousa A, Dinis-Oliveira RJ. <em>Pharmacokinetic and pharmacodynamic of the cognitive enhancer modafinil: Relevant clinical and forensic aspects<\/em>. Subst Abus. 2020;41:155-173. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31951804\/\" rel=\"nofollow noopener\" target=\"_blank\">31951804<\/a>. DOI: <a href=\"https:\/\/doi.org\/10.1080\/08897077.2019.1700584\" rel=\"nofollow noopener\" target=\"_blank\">10.1080\/08897077.2019.1700584<\/a>.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Removing the oxygen from the sulfoxide group eliminates the stereogenic center at sulfur and increases susceptibility to oxidation. What this means in practice.<\/p>\n","protected":false},"author":6,"featured_media":3778,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_daextinma_seo_power":"","_daextinma_enable_ail":"","footnotes":""},"categories":[1565],"tags":[],"class_list":["post-4022","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-history-and-synthesis"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Didesoxymodafinil: What Removing Two Oxygen Atoms Means - NONSENSIA, Laboratorium.<\/title>\n<meta name=\"description\" content=\"Removing oxygen from the sulfoxide group eliminates the stereogenic center at sulfur and raises susceptibility to oxidation. 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