"[\n    {\n        \"id\": \"molgod-534beb4847faa16f207172c09c653639\",\n        \"type\": \"article-journal\",\n        \"title\": \"Pharmacokinetic-Pharmacodynamic and Response Sensitization Modeling of the Intraocular Pressure-Lowering Effect of the EP4 Agonist 5-{3-[(2S)-2-{(3R)-3-hydroxy-4-[3-(trifluoromethyl)phenyl]butyl}-5-oxopyrrolidin-1-yl]propyl}thiophene-2-carboxylate (PF-04475270)\",\n        \"author\": [\n            {\n                \"family\": \"Luu\",\n                \"given\": \"K.\"\n            },\n            {\n                \"family\": \"Zhang\",\n                \"given\": \"Eric\"\n            },\n            {\n                \"family\": \"al.\",\n                \"given\": \"G. Prasanna et\"\n            }\n        ],\n        \"container-title\": \"Journal of Pharmacology and Experimental Therapeutics\",\n        \"issued\": {\n            \"date-parts\": [\n                [\n                    2009\n                ]\n            ]\n        },\n        \"DOI\": \"10.1124\\\/jpet.109.157800\",\n        \"PMID\": 19690190,\n        \"abstract\": \"A preclinical population-based PD model suitable for capturing the time course of dog intraocular pressure (IOP) that exhibited time-dependent sensitization after topical administration of PF-04475270 may have general utility when PD sensitization is observed and is not a result of time- dependent PK.\"\n    },\n    {\n        \"id\": \"molgod-a6632065171ce43dd2f877328d258035\",\n        \"type\": \"article-journal\",\n        \"title\": \"Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor.\",\n        \"author\": [\n            {\n                \"family\": \"Veinberg\",\n                \"given\": \"G.\"\n            },\n            {\n                \"family\": \"Vorona\",\n                \"given\": \"M.\"\n            },\n            {\n                \"family\": \"al.\",\n                \"given\": \"L. Zvejniece et\"\n            }\n        ],\n        \"container-title\": \"Bioorganic & Medicinal Chemistry\",\n        \"issued\": {\n            \"date-parts\": [\n                [\n                    2013\n                ]\n            ]\n        },\n        \"DOI\": \"10.1016\\\/j.bmc.2013.03.016\",\n        \"PMID\": 23582449,\n        \"URL\": \"https:\\\/\\\/doi.org\\\/10.7270\\\/q2n87c5q\",\n        \"abstract\": \"Experiments with electrically stimulated rat vas deference contractions induced by the PRE-084, an agonist of sigma-1 receptor, showed that (4R,5S)- and 2-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamides with an R-configuration at the C-4 chiral centre in the 2-pyrrolidsone ring were more effective positive allosteric modulators of\"\n    },\n    {\n        \"id\": \"molgod-4d26d9eb6f19db3fe9846aee1b099e78\",\n        \"type\": \"article-journal\",\n        \"title\": \"One-pot synthesis of substituted pyrrolo[3,4-b]pyridine-4,5-diones based on the reaction of N-(1-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-2-oxo-2-arylethyl)acetamide with amines\",\n        \"author\": [\n            {\n                \"family\": \"Melekhina\",\n                \"given\": \"V. G.\"\n            },\n            {\n                \"family\": \"Komogortsev\",\n                \"given\": \"A.\"\n            },\n            {\n                \"family\": \"al.\",\n                \"given\": \"B. Lichitsky et\"\n            }\n        ],\n        \"container-title\": \"Beilstein Journal of Organic Chemistry\",\n        \"issued\": {\n            \"date-parts\": [\n                [\n                    2019\n                ]\n            ]\n        },\n        \"DOI\": \"10.3762\\\/bjoc.15.277\",\n        \"PMID\": 31839829,\n        \"URL\": \"https:\\\/\\\/www.beilstein-journals.org\\\/bjoc\\\/content\\\/pdf\\\/1860-5397-15-277.pdf\",\n        \"abstract\": \"A practical and convenient one-pot synthetic method for substituted pyrrolo[3,4-b]pyridin-5-ones could be devised based on a previously unknown recyclization of the starting material in acidic ethanol in the presence of an amine.\"\n    },\n    {\n        \"id\": \"molgod-c844c6b6107dfbf360f702cf94dfd54c\",\n        \"type\": \"article-journal\",\n        \"title\": \"Role of P-Glycoprotein and the Intestine in the Excretion of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide] in Rodents\",\n        \"author\": [\n            {\n                \"family\": \"Garner\",\n                \"given\": \"C.\"\n            },\n            {\n                \"family\": \"Solon\",\n                \"given\": \"E.\"\n            },\n            {\n                \"family\": \"al.\",\n                \"given\": \"Chii\u2010Ming Lai et\"\n            }\n        ],\n        \"container-title\": \"Drug Metabolism And Disposition\",\n        \"issued\": {\n            \"date-parts\": [\n                [\n                    2008\n                ]\n            ]\n        },\n        \"DOI\": \"10.1124\\\/dmd.107.017038\",\n        \"PMID\": 18347085,\n        \"abstract\": \"The above data suggest that in the rodent the intestine serves as an organ of DPC 333 excretion, mediated in part by the transporter P-gp.\"\n    },\n    {\n        \"id\": \"molgod-3b351cc3880356b852146b701c84c563\",\n        \"type\": \"article-journal\",\n        \"title\": \"Studying the structure and evaluating \u03b1\u2010glucosidase inhibition of novel acetamide derivatives incorporating 4\u2010ethyl\u20104H\u20101,2,4\u2010triazole starting from 2\u2010(naphthalene\u20101\u2010yl)acetic acid\",\n        \"author\": [\n            {\n                \"family\": \"Le\",\n                \"given\": \"Trong Duc\"\n            },\n            {\n                \"family\": \"Cong\",\n                \"given\": \"Tien Nguyen\"\n            },\n            {\n                \"family\": \"al.\",\n                \"given\": \"Thi-Minh-Dinh Tran et\"\n            }\n        ],\n        \"container-title\": \"Asian Journal of Organic Chemistry\",\n        \"issued\": {\n            \"date-parts\": [\n                [\n                    2024\n                ]\n            ]\n        },\n        \"DOI\": \"10.1002\\\/ajoc.202400063\",\n        \"URL\": \"https:\\\/\\\/onlinelibrary.wiley.com\\\/doi\\\/pdfdirect\\\/10.1002\\\/ajoc.202400063\"\n    },\n    {\n        \"id\": \"molgod-03beec05dc1ccc43c83e3818100dbb06\",\n        \"type\": \"article-journal\",\n        \"title\": \"Ethyl 2-(4-hydroxy-3-methoxyphenyl)-1-[3-(2-oxopyrrolidin-1-yl)propyl]-1H-benzimidazole-5-carboxylate monohydrate\",\n        \"author\": [\n            {\n                \"family\": \"Yoon\",\n                \"given\": \"Y. K.\"\n            },\n            {\n                \"family\": \"Ali\",\n                \"given\": \"M. A.\"\n            },\n            {\n                \"family\": \"al.\",\n                \"given\": \"T. S. Choon et\"\n            }\n        ],\n        \"container-title\": \"Acta Crystallographica Section E\",\n        \"issued\": {\n            \"date-parts\": [\n                [\n                    2011\n                ]\n            ]\n        },\n        \"DOI\": \"10.1107\\\/S1600536811052391\",\n        \"PMID\": 22259586,\n        \"URL\": \"https:\\\/\\\/journals.iucr.org\\\/e\\\/issues\\\/2012\\\/01\\\/00\\\/is5022\\\/is5022.pdf\",\n        \"abstract\": \"In the title compound, C24H27N3O5\u00b7H2O, the essentially planar benzimidazole ring system forms dihedral angles of 54.10\u2005(11) and 67.79\u201d(6)\u00b0, respectively, with the mean plane of pyrrolidin-2-one ring and the benzene ring.\"\n    },\n    {\n        \"id\": \"molgod-5ca3dd4da4fa9c766fd52426c3ddde3e\",\n        \"type\": \"article-journal\",\n        \"title\": \"Efficacy and safety of L-oxiracetam on cognitive function in patients with traumatic brain injury: a multicentre, randomised, double-blind, phase 3 clinical trial.\",\n        \"author\": [\n            {\n                \"family\": \"T\",\n                \"given\": \"Liu\"\n            },\n            {\n                \"family\": \"J\",\n                \"given\": \"Wang\"\n            },\n            {\n                \"family\": \"al.\",\n                \"given\": \"Zhao Z et\"\n            }\n        ],\n        \"container-title\": \"Signal transduction and targeted therapy\",\n        \"issued\": {\n            \"date-parts\": [\n                [\n                    2025\n                ]\n            ]\n        },\n        \"DOI\": \"10.1038\\\/s41392-025-02492-5\",\n        \"PMID\": 41381424,\n        \"URL\": \"https:\\\/\\\/www.nature.com\\\/articles\\\/s41392-025-02492-5.pdf\"\n    },\n    {\n        \"id\": \"molgod-0fcaa1c8d130d2f206557ec1bf69c8e5\",\n        \"type\": \"article-journal\",\n        \"title\": \"Co-administration of Nanowired Oxiracetam and Neprilysin with Monoclonal Antibodies to Amyloid Beta Peptide and p-Tau Thwarted Exacerbation of Brain Pathology in Concussive Head Injury at Hot Environment.\",\n        \"author\": [\n            {\n                \"family\": \"A\",\n                \"given\": \"Nozari\"\n            },\n            {\n                \"family\": \"A\",\n                \"given\": \"Sharma\"\n            },\n            {\n                \"family\": \"al.\",\n                \"given\": \"Wang Z et\"\n            }\n        ],\n        \"container-title\": \"Advances in neurobiology\",\n        \"issued\": {\n            \"date-parts\": [\n                [\n                    2023\n                ]\n            ]\n        },\n        \"DOI\": \"10.1007\\\/978-3-031-32997-5_7\",\n        \"PMID\": 37480464\n    },\n    {\n        \"id\": \"molgod-86141a8ef564d2f92ec88a2fb1eb1807\",\n        \"type\": \"article-journal\",\n        \"title\": \"N-tert-Butyl-2-{2-[2-(4-chlorophenyl)-4-hydroxy-1-(5-methylisoxazol-3-yl)-5-oxo-2,5-dihydro-1H-pyrrol-3-yl]-N-(4-methoxyphenyl)acetamido}-2-(4-methoxyphenyl)acetamide methanol monosolvate: single-crystal X-ray diffraction study and Hirshfeld surface analysis\",\n        \"author\": [\n            {\n                \"family\": \"Shyshkina\",\n                \"given\": \"Mariia O\"\n            },\n            {\n                \"family\": \"Sakhno\",\n                \"given\": \"Yana I\"\n            },\n            {\n                \"family\": \"al.\",\n                \"given\": \"Oleksandr V Radchenko et\"\n            }\n        ],\n        \"container-title\": \"Acta Crystallographica Section E: Crystallographic Communications\",\n        \"issued\": {\n            \"date-parts\": [\n                [\n                    2021\n                ]\n            ]\n        },\n        \"DOI\": \"10.1107\\\/S2056989021011312\",\n        \"PMID\": 34925883,\n        \"URL\": \"https:\\\/\\\/journals.iucr.org\\\/e\\\/issues\\\/2021\\\/12\\\/00\\\/zq2268\\\/zq2268.pdf\"\n    },\n    {\n        \"id\": \"molgod-8cd998bdd85ede3e64b785aa9df3ff62\",\n        \"type\": \"article-journal\",\n        \"title\": \"[Oxiracetam].\",\n        \"author\": [\n            {\n                \"family\": \"R\",\n                \"given\": \"Gava\"\n            },\n            {\n                \"family\": \"F\",\n                \"given\": \"Schifano\"\n            }\n        ],\n        \"container-title\": \"Giornale di clinica medica\",\n        \"issued\": {\n            \"date-parts\": [\n                [\n                    1989\n                ]\n            ]\n        },\n        \"PMID\": 2668093\n    },\n    {\n        \"id\": \"molgod-881cc7b885e088a6d7a51c2f1fc7bd61\",\n        \"type\": \"article-journal\",\n        \"title\": \"Enhancement of contextual fear-conditioning by putative (+\\\/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor modulators and N-methyl-D-aspartate (NMDA) receptor antagonists in DBA\\\/2J mice.\",\n        \"author\": [\n            {\n                \"family\": \"Y\",\n                \"given\": \"Lu\"\n            },\n            {\n                \"family\": \"JM\",\n                \"given\": \"Wehner\"\n            }\n        ],\n        \"container-title\": \"Brain research\",\n        \"issued\": {\n            \"date-parts\": [\n                [\n                    1997\n                ]\n            ]\n        },\n        \"DOI\": \"10.1016\\\/s0006-8993(97)00644-6\",\n        \"PMID\": 9369316\n    },\n    {\n        \"id\": \"molgod-ddb4397bd4ce96778ac948380f02b0b8\",\n        \"type\": \"article-journal\",\n        \"title\": \"Synthesis and nootropic activity of 2-oxo-1-pyrrolidinesulfonic acid derivatives.\",\n        \"author\": [\n            {\n                \"family\": \"A\",\n                \"given\": \"Cerri\"\n            },\n            {\n                \"family\": \"C\",\n                \"given\": \"Farina\"\n            },\n            {\n                \"family\": \"al.\",\n                \"given\": \"Pinza M et\"\n            }\n        ],\n        \"container-title\": \"Farmaco (Societa chimica italiana : 1989)\",\n        \"issued\": {\n            \"date-parts\": [\n                [\n                    1991\n                ]\n            ]\n        },\n        \"PMID\": 1793478\n    },\n    {\n        \"id\": \"molgod-ed469e595b6c7918028b55d1764e0045\",\n        \"type\": \"article-journal\",\n        \"title\": \"Enhancement of hippocampally-mediated learning and protein kinase C activity by oxiracetam in learning-impaired DBA\\\/2 mice.\",\n        \"author\": [\n            {\n                \"family\": \"DE\",\n                \"given\": \"Fordyce\"\n            },\n            {\n                \"family\": \"VJ\",\n                \"given\": \"Clark\"\n            },\n            {\n                \"family\": \"al.\",\n                \"given\": \"Paylor R et\"\n            }\n        ],\n        \"container-title\": \"Brain research\",\n        \"issued\": {\n            \"date-parts\": [\n                [\n                    1995\n                ]\n            ]\n        },\n        \"DOI\": \"10.1016\\\/0006-8993(94)01389-y\",\n        \"PMID\": 7749739\n    },\n    {\n        \"id\": \"molgod-ce1e3b98cbf3cce08e8f32bb2ed481b9\",\n        \"type\": \"article-journal\",\n        \"title\": \"Treatment with oxiracetam or choline restores cholinergic biochemical and pharmacological activities in striata of decorticated rats.\",\n        \"author\": [\n            {\n                \"family\": \"S\",\n                \"given\": \"Consolo\"\n            },\n            {\n                \"family\": \"P\",\n                \"given\": \"Salmoiraghi\"\n            },\n            {\n                \"family\": \"al.\",\n                \"given\": \"Amoroso D et\"\n            }\n        ],\n        \"container-title\": \"Journal of neurochemistry\",\n        \"issued\": {\n            \"date-parts\": [\n                [\n                    1990\n                ]\n            ]\n        },\n        \"DOI\": \"10.1111\\\/j.1471-4159.1990.tb01909.x\",\n        \"PMID\": 2299354\n    },\n    {\n        \"id\": \"molgod-7a8ccdaa4ffa5c68816362630ab962df\",\n        \"type\": \"article-journal\",\n        \"title\": \"Multi-infarct dementia: prevention and treatment.\",\n        \"author\": [\n            {\n                \"family\": \"JP\",\n                \"given\": \"Wade\"\n            }\n        ],\n        \"container-title\": \"Alzheimer disease and associated disorders\",\n        \"issued\": {\n            \"date-parts\": [\n                [\n                    1991\n                ]\n            ]\n        },\n        \"DOI\": \"10.1097\\\/00002093-199100520-00011\",\n        \"PMID\": 2059406\n    },\n    {\n        \"id\": \"molgod-a2875528060bb87bbfca08e5b58dbabc\",\n        \"type\": \"article-journal\",\n        \"title\": \"Effect of oxiracetam on cerebrovascular impairment in rats.\",\n        \"author\": [\n            {\n                \"family\": \"M\",\n                \"given\": \"Kometani\"\n            },\n            {\n                \"family\": \"M\",\n                \"given\": \"Okada\"\n            },\n            {\n                \"family\": \"al.\",\n                \"given\": \"Takemori E et\"\n            }\n        ],\n        \"container-title\": \"Arzneimittel-Forschung\",\n        \"issued\": {\n            \"date-parts\": [\n                [\n                    1991\n                ]\n            ]\n        },\n        \"PMID\": 1772453\n    },\n    {\n        \"id\": \"molgod-02b2c3cd8d83576d32ea008cb8b7ecd1\",\n        \"type\": \"article-journal\",\n        \"title\": \"Oxiracetam alleviates anti-inflammatory activity and ameliorates cognitive impairment in the early phase of traumatic brain injury.\",\n        \"author\": [\n            {\n                \"family\": \"DH\",\n                \"given\": \"Youn\"\n            },\n            {\n                \"family\": \"SW\",\n                \"given\": \"Han\"\n            },\n            {\n                \"family\": \"al.\",\n                \"given\": \"Kim JT et\"\n            }\n        ],\n        \"container-title\": \"Acta neurochirurgica\",\n        \"issued\": {\n            \"date-parts\": [\n                [\n                    2023\n                ]\n            ]\n        },\n        \"DOI\": \"10.1007\\\/s00701-023-05674-8\",\n        \"PMID\": 37380907\n    },\n    {\n        \"id\": \"molgod-852abbe47dae8cfecc3c4e55a7de1600\",\n        \"type\": \"article-journal\",\n        \"title\": \"Oxiracetam and D-pyroglutamic acid antagonize a disruption of passive avoidance behaviour induced by the N-methyl-D-aspartate receptor antagonist 2-amino-5-phosphonovalerate.\",\n        \"author\": [\n            {\n                \"family\": \"F\",\n                \"given\": \"Paoli\"\n            },\n            {\n                \"family\": \"G\",\n                \"given\": \"Spignoli\"\n            },\n            {\n                \"family\": \"G\",\n                \"given\": \"Pepeu\"\n            }\n        ],\n        \"container-title\": \"Psychopharmacology\",\n        \"issued\": {\n            \"date-parts\": [\n                [\n                    1990\n                ]\n            ]\n        },\n        \"DOI\": \"10.1007\\\/BF02245803\",\n        \"PMID\": 2153307\n    },\n    {\n        \"id\": \"molgod-eb1f11b5f9093c62813e731b5acaa6da\",\n        \"type\": \"article-journal\",\n        \"title\": \"Pharmacokinetic Properties of S-oxiracetam After Single and Multiple Intravenous Infusions in Healthy Volunteers.\",\n        \"author\": [\n            {\n                \"family\": \"D\",\n                \"given\": \"Liang\"\n            },\n            {\n                \"family\": \"J\",\n                \"given\": \"Shen\"\n            },\n            {\n                \"family\": \"al.\",\n                \"given\": \"Jia Y et\"\n            }\n        ],\n        \"container-title\": \"European journal of drug metabolism and pharmacokinetics\",\n        \"issued\": {\n            \"date-parts\": [\n                [\n                    2021\n                ]\n            ]\n        },\n        \"DOI\": \"10.1007\\\/s13318-021-00718-9\",\n        \"PMID\": 34549388\n    },\n    {\n        \"id\": \"molgod-68340ecdd3945a907c6ca984b5dc2e3c\",\n        \"type\": \"article-journal\",\n        \"title\": \"Bone marrow stromal cells combined with oxiracetam influences the expression of B-cell lymphoma 2 in rats with ischemic stroke.\",\n        \"author\": [\n            {\n                \"family\": \"C\",\n                \"given\": \"Wang\"\n            },\n            {\n                \"family\": \"F\",\n                \"given\": \"Li\"\n            },\n            {\n                \"family\": \"al.\",\n                \"given\": \"Guan Y et\"\n            }\n        ],\n        \"container-title\": \"Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association\",\n        \"issued\": {\n            \"date-parts\": [\n                [\n                    2014\n                ]\n            ]\n        },\n        \"DOI\": \"10.1016\\\/j.jstrokecerebrovasdis.2014.05.035\",\n        \"PMID\": 25267587\n    }\n]"