The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration<\/title><secondary-title>PLoS Medicine<\/secondary-title><\/titles><dates><year>2009<\/year><\/dates><electronic-resource-num>10.1371\/journal.pmed.1000100<\/electronic-resource-num><urls><related-urls><url>https:\/\/journals.plos.org\/plosmedicine\/article\/file?id=10.1371\/journal.pmed.1000100&type=printable<\/url><\/related-urls><\/urls><\/record>\n<record><database name=\"MolGod\">MolGod<\/database><source-app name=\"MOL-GOD\" version=\"3.1.4\">MOL-GOD<\/source-app><rec-number>2<\/rec-number><ref-type name=\"Journal Article\">17<\/ref-type><contributors><authors><author>Jeroen S. Kok<\/author><author>Ina J. Berg<\/author><author>Erik Scherder<\/author><\/authors><\/contributors><titles><title>Special Care Units and Traditional Care in Dementia: Relationship with Behavior, Cognition, Functional Status and Quality of Life - A Review<\/title><secondary-title>Dementia and Geriatric Cognitive Disorders Extra<\/secondary-title><\/titles><dates><year>2013<\/year><\/dates><electronic-resource-num>10.1159\/000353441<\/electronic-resource-num><urls><related-urls><url>https:\/\/karger.com\/dee\/article-pdf\/3\/1\/360\/2562810\/000353441.pdf<\/url><\/related-urls><\/urls><\/record>\n<record><database name=\"MolGod\">MolGod<\/database><source-app name=\"MOL-GOD\" version=\"3.1.4\">MOL-GOD<\/source-app><rec-number>3<\/rec-number><ref-type name=\"Journal Article\">17<\/ref-type><contributors><authors><author>Stephen F. Altschul<\/author><\/authors><\/contributors><titles><title>Gapped BLAST and PSI-BLAST: a new generation of protein database search programs<\/title><secondary-title>Nucleic Acids Research<\/secondary-title><\/titles><dates><year>1997<\/year><\/dates><electronic-resource-num>10.1093\/nar\/25.17.3389<\/electronic-resource-num><urls><related-urls><url>https:\/\/academic.oup.com\/nar\/article-pdf\/25\/17\/3389\/3639509\/25-17-3389.pdf<\/url><\/related-urls><\/urls><\/record>\n<record><database name=\"MolGod\">MolGod<\/database><source-app name=\"MOL-GOD\" version=\"3.1.4\">MOL-GOD<\/source-app><rec-number>4<\/rec-number><ref-type name=\"Journal Article\">17<\/ref-type><contributors><authors><author>Ahmedin Jemal<\/author><author>Freddie Bray<\/author><author>Jacques Ferlay et al.<\/author><\/authors><\/contributors><titles><title>Global cancer statistics<\/title><secondary-title>CA A Cancer Journal for Clinicians<\/secondary-title><\/titles><dates><year>2011<\/year><\/dates><electronic-resource-num>10.3322\/caac.20107<\/electronic-resource-num><urls><related-urls><url>https:\/\/onlinelibrary.wiley.com\/doi\/pdfdirect\/10.3322\/caac.20107<\/url><\/related-urls><\/urls><\/record>\n<record><database name=\"MolGod\">MolGod<\/database><source-app name=\"MOL-GOD\" version=\"3.1.4\">MOL-GOD<\/source-app><rec-number>5<\/rec-number><ref-type name=\"Journal Article\">17<\/ref-type><contributors><authors><author>Tianqi Chen<\/author><author>Carlos Guestrin<\/author><\/authors><\/contributors><titles><title>XGBoost<\/title><secondary-title><\/secondary-title><\/titles><dates><year>2016<\/year><\/dates><electronic-resource-num>10.1145\/2939672.2939785<\/electronic-resource-num><urls><related-urls><url>http:\/\/dl.acm.org\/ft_gateway.cfm?id=2939785&type=pdf<\/url><\/related-urls><\/urls><\/record>\n<record><database name=\"MolGod\">MolGod<\/database><source-app name=\"MOL-GOD\" version=\"3.1.4\">MOL-GOD<\/source-app><rec-number>6<\/rec-number><ref-type name=\"Journal Article\">17<\/ref-type><contributors><authors><author>Lindsey A. Torre<\/author><author>Freddie Bray<\/author><author>Rebecca L. Siegel et al.<\/author><\/authors><\/contributors><titles><title>Global cancer statistics, 2012<\/title><secondary-title>CA A Cancer Journal for Clinicians<\/secondary-title><\/titles><dates><year>2015<\/year><\/dates><electronic-resource-num>10.3322\/caac.21262<\/electronic-resource-num><urls><related-urls><url>https:\/\/onlinelibrary.wiley.com\/doi\/pdfdirect\/10.3322\/caac.21262<\/url><\/related-urls><\/urls><\/record>\n<record><database name=\"MolGod\">MolGod<\/database><source-app name=\"MOL-GOD\" version=\"3.1.4\">MOL-GOD<\/source-app><rec-number>7<\/rec-number><ref-type name=\"Journal Article\">17<\/ref-type><contributors><authors><author>Christiam Camacho<\/author><author>George Coulouris<\/author><author>Vahram Avagyan et al.<\/author><\/authors><\/contributors><titles><title>BLAST+: architecture and applications<\/title><secondary-title>BMC Bioinformatics<\/secondary-title><\/titles><dates><year>2009<\/year><\/dates><electronic-resource-num>10.1186\/1471-2105-10-421<\/electronic-resource-num><urls><related-urls><url>https:\/\/bmcbioinformatics.biomedcentral.com\/counter\/pdf\/10.1186\/1471-2105-10-421<\/url><\/related-urls><\/urls><\/record>\n<record><database name=\"MolGod\">MolGod<\/database><source-app name=\"MOL-GOD\" version=\"3.1.4\">MOL-GOD<\/source-app><rec-number>8<\/rec-number><ref-type name=\"Journal Article\">17<\/ref-type><contributors><authors><author>Sylvain Foissac<\/author><\/authors><\/contributors><titles><title>An integrated encyclopedia of DNA elements in the human genome<\/title><secondary-title>Nature<\/secondary-title><\/titles><dates><year>2012<\/year><\/dates><electronic-resource-num>10.1038\/nature11247<\/electronic-resource-num><urls><related-urls><url>https:\/\/www.nature.com\/articles\/nature11247.pdf<\/url><\/related-urls><\/urls><\/record>\n<record><database name=\"MolGod\">MolGod<\/database><source-app name=\"MOL-GOD\" version=\"3.1.4\">MOL-GOD<\/source-app><rec-number>9<\/rec-number><ref-type name=\"Journal Article\">17<\/ref-type><contributors><authors><author>Theo Vos<\/author><author>Stephen S Lim<\/author><author>Cristiana Abbafati et al.<\/author><\/authors><\/contributors><titles><title>Global burden of 369 diseases and injuries in 204 countries and territories, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019<\/title><secondary-title>The Lancet<\/secondary-title><\/titles><dates><year>2020<\/year><\/dates><electronic-resource-num>10.1016\/s0140-6736(20)30925-9<\/electronic-resource-num><urls><related-urls><url>http:\/\/www.thelancet.com\/article\/S0140673620309259\/pdf<\/url><\/related-urls><\/urls><\/record>\n<record><database name=\"MolGod\">MolGod<\/database><source-app name=\"MOL-GOD\" version=\"3.1.4\">MOL-GOD<\/source-app><rec-number>10<\/rec-number><ref-type name=\"Journal Article\">17<\/ref-type><contributors><authors><author>Antoine Daina<\/author><author>Olivier Michielin<\/author><author>Vincent Zoete<\/author><\/authors><\/contributors><titles><title>SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules<\/title><secondary-title>Scientific Reports<\/secondary-title><\/titles><dates><year>2017<\/year><\/dates><electronic-resource-num>10.1038\/srep42717<\/electronic-resource-num><urls><related-urls><url>https:\/\/www.nature.com\/articles\/srep42717.pdf<\/url><\/related-urls><\/urls><\/record>\n<record><database name=\"MolGod\">MolGod<\/database><source-app name=\"MOL-GOD\" version=\"3.1.4\">MOL-GOD<\/source-app><rec-number>11<\/rec-number><ref-type name=\"Journal Article\">17<\/ref-type><contributors><authors><author>OliverH. 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"\n\nMolGod<\/database>MOL-GOD<\/source-app>1<\/rec-number>17<\/ref-type>Alessandro Liberati<\/author>Douglas G. Altman<\/author>Jennifer Tetzlaff et al.<\/author><\/authors><\/contributors>The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration<\/title><secondary-title>PLoS Medicine<\/secondary-title><\/titles><dates><year>2009<\/year><\/dates><electronic-resource-num>10.1371\/journal.pmed.1000100<\/electronic-resource-num><urls><related-urls><url>https:\/\/journals.plos.org\/plosmedicine\/article\/file?id=10.1371\/journal.pmed.1000100&type=printable<\/url><\/related-urls><\/urls><\/record>\n<record><database name=\"MolGod\">MolGod<\/database><source-app name=\"MOL-GOD\" version=\"3.1.4\">MOL-GOD<\/source-app><rec-number>2<\/rec-number><ref-type name=\"Journal Article\">17<\/ref-type><contributors><authors><author>Jeroen S. Kok<\/author><author>Ina J. Berg<\/author><author>Erik Scherder<\/author><\/authors><\/contributors><titles><title>Special Care Units and Traditional Care in Dementia: Relationship with Behavior, Cognition, Functional Status and Quality of Life - A Review<\/title><secondary-title>Dementia and Geriatric Cognitive Disorders Extra<\/secondary-title><\/titles><dates><year>2013<\/year><\/dates><electronic-resource-num>10.1159\/000353441<\/electronic-resource-num><urls><related-urls><url>https:\/\/karger.com\/dee\/article-pdf\/3\/1\/360\/2562810\/000353441.pdf<\/url><\/related-urls><\/urls><\/record>\n<record><database name=\"MolGod\">MolGod<\/database><source-app name=\"MOL-GOD\" version=\"3.1.4\">MOL-GOD<\/source-app><rec-number>3<\/rec-number><ref-type name=\"Journal Article\">17<\/ref-type><contributors><authors><author>Stephen F. Altschul<\/author><\/authors><\/contributors><titles><title>Gapped BLAST and PSI-BLAST: a new generation of protein database search programs<\/title><secondary-title>Nucleic Acids Research<\/secondary-title><\/titles><dates><year>1997<\/year><\/dates><electronic-resource-num>10.1093\/nar\/25.17.3389<\/electronic-resource-num><urls><related-urls><url>https:\/\/academic.oup.com\/nar\/article-pdf\/25\/17\/3389\/3639509\/25-17-3389.pdf<\/url><\/related-urls><\/urls><\/record>\n<record><database name=\"MolGod\">MolGod<\/database><source-app name=\"MOL-GOD\" version=\"3.1.4\">MOL-GOD<\/source-app><rec-number>4<\/rec-number><ref-type name=\"Journal Article\">17<\/ref-type><contributors><authors><author>Ahmedin Jemal<\/author><author>Freddie Bray<\/author><author>Jacques Ferlay et al.<\/author><\/authors><\/contributors><titles><title>Global cancer statistics<\/title><secondary-title>CA A Cancer Journal for Clinicians<\/secondary-title><\/titles><dates><year>2011<\/year><\/dates><electronic-resource-num>10.3322\/caac.20107<\/electronic-resource-num><urls><related-urls><url>https:\/\/onlinelibrary.wiley.com\/doi\/pdfdirect\/10.3322\/caac.20107<\/url><\/related-urls><\/urls><\/record>\n<record><database name=\"MolGod\">MolGod<\/database><source-app name=\"MOL-GOD\" version=\"3.1.4\">MOL-GOD<\/source-app><rec-number>5<\/rec-number><ref-type name=\"Journal Article\">17<\/ref-type><contributors><authors><author>Tianqi Chen<\/author><author>Carlos Guestrin<\/author><\/authors><\/contributors><titles><title>XGBoost<\/title><secondary-title><\/secondary-title><\/titles><dates><year>2016<\/year><\/dates><electronic-resource-num>10.1145\/2939672.2939785<\/electronic-resource-num><urls><related-urls><url>http:\/\/dl.acm.org\/ft_gateway.cfm?id=2939785&type=pdf<\/url><\/related-urls><\/urls><\/record>\n<record><database name=\"MolGod\">MolGod<\/database><source-app name=\"MOL-GOD\" version=\"3.1.4\">MOL-GOD<\/source-app><rec-number>6<\/rec-number><ref-type name=\"Journal Article\">17<\/ref-type><contributors><authors><author>Lindsey A. Torre<\/author><author>Freddie Bray<\/author><author>Rebecca L. Siegel et al.<\/author><\/authors><\/contributors><titles><title>Global cancer statistics, 2012<\/title><secondary-title>CA A Cancer Journal for Clinicians<\/secondary-title><\/titles><dates><year>2015<\/year><\/dates><electronic-resource-num>10.3322\/caac.21262<\/electronic-resource-num><urls><related-urls><url>https:\/\/onlinelibrary.wiley.com\/doi\/pdfdirect\/10.3322\/caac.21262<\/url><\/related-urls><\/urls><\/record>\n<record><database name=\"MolGod\">MolGod<\/database><source-app name=\"MOL-GOD\" version=\"3.1.4\">MOL-GOD<\/source-app><rec-number>7<\/rec-number><ref-type name=\"Journal Article\">17<\/ref-type><contributors><authors><author>Christiam Camacho<\/author><author>George Coulouris<\/author><author>Vahram Avagyan et al.<\/author><\/authors><\/contributors><titles><title>BLAST+: architecture and applications<\/title><secondary-title>BMC Bioinformatics<\/secondary-title><\/titles><dates><year>2009<\/year><\/dates><electronic-resource-num>10.1186\/1471-2105-10-421<\/electronic-resource-num><urls><related-urls><url>https:\/\/bmcbioinformatics.biomedcentral.com\/counter\/pdf\/10.1186\/1471-2105-10-421<\/url><\/related-urls><\/urls><\/record>\n<record><database name=\"MolGod\">MolGod<\/database><source-app name=\"MOL-GOD\" version=\"3.1.4\">MOL-GOD<\/source-app><rec-number>8<\/rec-number><ref-type name=\"Journal Article\">17<\/ref-type><contributors><authors><author>Sylvain Foissac<\/author><\/authors><\/contributors><titles><title>An integrated encyclopedia of DNA elements in the human genome<\/title><secondary-title>Nature<\/secondary-title><\/titles><dates><year>2012<\/year><\/dates><electronic-resource-num>10.1038\/nature11247<\/electronic-resource-num><urls><related-urls><url>https:\/\/www.nature.com\/articles\/nature11247.pdf<\/url><\/related-urls><\/urls><\/record>\n<record><database name=\"MolGod\">MolGod<\/database><source-app name=\"MOL-GOD\" version=\"3.1.4\">MOL-GOD<\/source-app><rec-number>9<\/rec-number><ref-type name=\"Journal Article\">17<\/ref-type><contributors><authors><author>Theo Vos<\/author><author>Stephen S Lim<\/author><author>Cristiana Abbafati et al.<\/author><\/authors><\/contributors><titles><title>Global burden of 369 diseases and injuries in 204 countries and territories, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019<\/title><secondary-title>The Lancet<\/secondary-title><\/titles><dates><year>2020<\/year><\/dates><electronic-resource-num>10.1016\/s0140-6736(20)30925-9<\/electronic-resource-num><urls><related-urls><url>http:\/\/www.thelancet.com\/article\/S0140673620309259\/pdf<\/url><\/related-urls><\/urls><\/record>\n<record><database name=\"MolGod\">MolGod<\/database><source-app name=\"MOL-GOD\" version=\"3.1.4\">MOL-GOD<\/source-app><rec-number>10<\/rec-number><ref-type name=\"Journal Article\">17<\/ref-type><contributors><authors><author>Antoine Daina<\/author><author>Olivier Michielin<\/author><author>Vincent Zoete<\/author><\/authors><\/contributors><titles><title>SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules<\/title><secondary-title>Scientific Reports<\/secondary-title><\/titles><dates><year>2017<\/year><\/dates><electronic-resource-num>10.1038\/srep42717<\/electronic-resource-num><urls><related-urls><url>https:\/\/www.nature.com\/articles\/srep42717.pdf<\/url><\/related-urls><\/urls><\/record>\n<record><database name=\"MolGod\">MolGod<\/database><source-app name=\"MOL-GOD\" version=\"3.1.4\">MOL-GOD<\/source-app><rec-number>11<\/rec-number><ref-type name=\"Journal Article\">17<\/ref-type><contributors><authors><author>OliverH. 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